IFOSFAMID (Ifosfamide).

     N, 3-bis (2-Chloroethane) tetrahydro-2 H-1, 3,2-oksazafosforin-2- amin-2- oxide.

     Synonym : Holoksan, Holoxan.

     The white crystalline powder. Mg in the water.

     Arrangement and the mechanism of close to tsiklofosfanu.

     Assign (in combination with judging) with soft tissue sarcoma, cancer of light, Ewing sarcoma, lymphoma, chlamydia, breast cancer, cervical, ovarian, testicular tumors, limfoblastnom acute leukemia, chronic lymphoblastic, tumors in children (sarcoma, tumors Williams, Neuroblastoma, Germ tumors, malignant lymphoma).

     Intravenously applied only to 3,5-5 g / m 2 1 every 2 weeks or 1,2-2 g / m within 3-5 days every 3 weeks or 10 g / m 2 1 every 3-4 weeks.

     Possible side effects : neurotoxicity, drowsiness, nefrotoksichnost, nausea, vomiting, stomatitis, Alopecia, moderate radiation, allergic reactions.

     Contraindications : radiation, the effects on the kidneys, a urinary infection, pregnancy, breast-feeding.

     Ifosfamide should not appoint to the content in the blood leukocyte count less than 2? 109 / l and platelets less than 50? 109 litres.

     Product : dried powder for solution to internal introduction in vials of 0.2; 0.5; 1 and 2 grams.

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