GIDROKSIZIN (Hydroxyzine).

      2-[2-[4-A para-Hlor- fenilbenzil] -1 - piperazinil] - etoksi] ethanol.

 

      Available as hydrochloride.

      Synonyms : Ataraks, Alamon, Arcanax, Atara, Atarax, Atazin, Clorixin, Disron, Durrax, Forticalman, Hyzine, Iremoxin, Multipax, Neocalma, Neurolax, Orgatrax, Placidol, Quiess, Ucerax.

      Gidroksizin was one of the first N1- gistaminovyh receptor blockers. However, he has a sedative and anxiolytic effects; M has holinoliticheskimi and antiemetics properties.

      On chemical structure similar to some modern protivogistaminnym drugs (see Tsetirizin), but as protivogistaminnoe (antiallergic) means now is not widely used, and was used as a relatively "soft" trankviliziruyuschego funds.

      When ingestion absorbed quickly, with max of 2 h, T? - 12-24 h.

      Indications for use mostly elevated anxiety, stress, anxiety, alcohol withdrawal syndrome, sedation. Used also (for the protivogistaminnoy activity) in zudyaschih Medicine.

      There are performance gidroksizina with kardionevroticheskih disorders.

      Inside designate an adult to 0.01, or 0,025 grams (10 or 25 mg) of the total daily dose 0,025-0,1 g (25-100 mg), as appropriate, to 0.3 grams per day ; Children enter the rate of 1 mg / kg / day (a few tricks). Applied usually within four weeks. In anasteziologii appoint 0,1-0,2 g at night before the operation.

      In severe cases may initiate a intramuscular (2 ml of 5% solution of 0,1-d).

      When using drugs sometimes are drowsiness, weakness, dizziness, dry mouth and other side effects.

      The drug is not suitable for kidney and liver failure, porphyria, glaucoma risk of stroke, the isolationist prostate gland (at the antiholinergicheskimi properties drugs), pregnancy, breast-feeding.

 

      Method of production : tablets of 0.01 and 0.025 g (10 and 25 mg) (N 25); 0.2% in syrup bottles po200 ml; 5% solution in ampoules of 2 ml (0.1 g).

Materials allowed to copy only with the active hyperlink to the handbook of medicines