GEKSAMIDIN (Hexamidinum). 5-Etil-5- fenilgeksagidropirimidindion-4, 6.

     Synonyms : Primidon, Desoxyphenobarbitone, Lepimidin, Lespiral, Liskantin, Mizodin, Mylepsin, Mysoline, Prilepsin, Primaclone, Primidonum, Primidone, Primoline, Prysoline, Sedilen, Sertan and others.

     White kristalichesky powder. Almost nerastvorim in the water, little is soluble in alcohol.

     On chemical structure is dezoksibarbituratom; Phenobarbital is different from that of two carbonyl group (C == O) replaced by metilenovuyu (SN2). This chemical modification of the molecule led to a drug with strong convulsants of sleeping pills and less effect.

     When ingestion Primidone quickly and almost completely absorbed. The peak concentration in plasma is about 3 hours Period polususchestvovaniya plasma is 7-14 h. The drug is metabolized education phenobarbital (about 20%) and other active metabolite - feniletilmalonamida. About 40% is allocated to the product unchanged in urine.

     Primidone applied mainly to large fits of convulsions (grand mal). Less effective in light of abortifacients fits and mental equivalents. In small forms of epilepsy is not provided, but in some cases there has therapeutic effects.

     Is inside after eating. Initial daily intake for adults 0,125 g (1 - 2 admission), and then gradually increase the dose to 0,5-1 grams a day.

     Higher doses for adults : single 0.75 grams daily 2 grams.

     Children, depending on age designate of 0,125 to 0.5 grams per day.

     In the early days of treatment geksamidinom possible light disturbances, dizziness, headache, ataxy, nausea. These phenomena are usually alone. If necessary, gradually reduce the dose of medication, or cancel, but a few days appoint a reduced dose. The long reception geksamidina in high doses can lead to adverse neurological and psychiatric disorders, haematological complications (radiation, limfotsitoz, anaemia).

     Primidone aggravating habit of derivatives sulfanilmocheviny, tsiklofosfamida, methotrexate. Boosting activity mikrosomalnyh liver enzymes, it accelerates biotransformation coumarin derivatives, oestrogen contraceptive grizeofulvina, doxycycline.

     In appointing geksamidina pregnant and breastfeeding should be kept in mind that it acts similar to phenobarbital.

     With long-term use can develop geksamidina deficit folic acid in the body.

     The drug is contraindicated in violation of the liver, kidneys, blood system.

     Product : pills to 0,125 and 0.25 g pack of 50 pieces.

     Storage : List B. The well ukuporennoy packaging.

     Abroad, under the same title (Hexamidinum, Hexamidine) issued another drug-4, 4 - (geksametilendioksi) - dibenzamidin, a chemotherapy antiprotozoynym funds.

Materials allowed to copy only with the active hyperlink to the handbook of medicines