GRANISETRON (Granisetron).

     Metil-N- 1-(9-methyl endo-9- azabitsiklo [3,3,1] non-3- d) -1 H indazol-3- karboksamid.

     Synonym : Kitril, Kytril.

     White powder. Mg in the water.

     The structure has similarities with tropindolom (tropisetronom).

     For action is, like ondansetronu (see) and tropindolu (see), antiemetics means blokatorom serotonin 5-NT3- receptors.

     If ingestion is well absorbed in the digestive tract; Biotransformation exposed in the liver, bile appears mainly.

     Used for prevention and treatment of nausea and vomiting with therapy and cytotoxic drugs in the aftercare period.

     Assign inside and intravenously.

     Inside designate adults and children over 12 years of 0,001 grams (1 mg), 2 times a day in a cytostatic therapy. The first doses are not more than one hour before the start of cytostatic agents. The maximum daily intake does not exceed 0,009 grams (9 mg).

     For injecting the contents of one vial (3 mg) to throw in 20-50 ml of sterile 0.9% sodium chloride solution, or 5% glucose solution, or 10% solution mannitola and set for 5 minutes. For the prevention of nausea and vomiting use one every day (sometimes 2-3 times) for 5 days. Introduction finish before treatment cytostatica. In therapy drug is used in the same doses as for prevention. If necessary, additional Infusion spend at intervals not less than 10 min. The maximum daily dose of 0,009 grams (9 mg) (3 Infusion of 3 mg). Children entering (intravenously) to 0.04 mg / kg (no more than 3 mg) once (in 10-30 ml Tank solution) for 5 min.

     In applying the drug may headache, allergic reactions, constipation, increasing transaminaz liver.

     Do not appoint pregnancy and breastfeeding.

     Not to be confused with solutions granisetrona other LAN solutions. Solution granisetrona to prepare ex tempore (stored at room temperature for no more than 24 hours in a cool place protected from the light).

     Method of issuance : pills to 0,001 g (1 mg) (N 10); 0.1% concentrate for infusions of injectable and 3 ml (N 5).

     Storage : List B.

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