GOZERELIN (Goserelin).

     Synonym : Zoladeks, Zoladex.

     Synthetic dekapeptid-analogue gonadotropin- rilizing- factor (C59H84N18O14).

     As of close to buserelinu (see).

     A max is 1,5-3 h (high level maintained during 12-15 days for men and 22 days for women), T? - 2,5-4 hours

     Gormonozavisimom applied to prostate cancer and breast cancer, endometriosis, uterine fibroma.

     Available in a special apparatus Depo-rod (capsules) cylindrical containing 3.6 or 10.8 mg gozerelina acetate, biodegradiruemuyu included in the polymer matrix. The rod is in a special syringe. Diluted give subcutaneous fibre front wall of the abdomen : one 3.6 mg every 28 days; 10.8 1 mg every 3 months. When treating prostate cancer used in combination with anti-drugs.

     The duration of treatment to six months.

     Possible side effects : male-road violation disorders; Women-tides, fluctuating blood pressure, obstruction of menstrual flow, skin allergic reactions.

     The drug is contraindicated in pregnancy and breastfeeding.

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