GLYUKAGON (Glucagon).

     Synonym : GlyukaGen GipoKit, GlucaGen HypoKit.

     Hormone formulated? Cell-Langergansa pancreatic islets.

     Polypeptide (C153H325N43O49S), which consists of 29 amino acid residues.

     Contact with specific receptors in the liver cells, and skeletal muscles, activates adenilattsiklazu that brings in tsAMF ATF, which is stimulating activity fosforilazy, rasscheplyayuschey Green, and the suppression of activity glikogensintetazy and as a result, the increase in glyukoneogeneza glikogenoliza and in the liver and increases the concentration of glucose in the blood. It has also positive inotropnoy and spasmolytic activity.

     Glucagon rapidly metabolized in the liver and kidneys (T? 10 minutes).

     Applied primarily for edema hypoglycemia, in a developing insulin overdose (see), usually in combination with carbohydrates (glucose solution).

     Using well as poisoning? Adrenoblokatorami-blockers and calcium channel.

     Enter into the skin, intramuscularly or intravenously to adults 0,5-1 mg (if necessary repeat injections after 12 minutes); Child-0,025 mg / kg.

     When poisoning? - Adrenoblokatorami injected an estimated 0,005-0,15 mg / kg, then drip Quick 1-5 mg per hour, in the administration of calcium channel blockers - 0,002 grams (2 mg) once.

     In overdose may occur nausea, vomiting, allergic reactions. These phenomena, however, are rapidly.

     Pregnant women Glucagon appointed only in acute need. Not recommended medication during breastfeeding.

     Glucagon is not suitable for insulin (perhaps paradoxical development hypoglycemic reaction) and feohromatsitome (stimulates the release of catecholamines in the blood).

     Product : dried powder for injection solutions in vials of 0,001 and 0.01 g (1 and 10 mg) together with the solvent. There are also other (mnogodozovye) dosage forms.

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