GLIBENKLAMID (Glibenclamidum).

     N-[4-[2 - (5-Hlor-2- metoksibenzamido) - ethyl] - azides] -N- Cyclohexyl urea.

     Synonyms : Gilemal, Daonil, Maninil, Adiab, Betanase (Betaneyz) Clamid, Daonil, Digaben, Euclamin, Euglucon, Gilemal, Glicemin, Glucolon, Glibenclamide, Glyburide, Maninil, Miglucan, Normodiabet and others.

     White or white with a barely noticeable shade kremovatym melkokristallichesky powder. Almost nerastvorim in the water, little is soluble in alcohol.

     Like other antidiabetics sulfonylureas derivative is a motivational b-cells pancreas.

     Compared with the first-generation drugs (butamid, hlorpropamid, etc.) is more active (in effect is much smaller doses), BAS quick, relatively reasonable.

     The maximum concentration in the blood after a single admission found in 1 - 2 h duration of the 8 - 12 pm

     In some cases, effective with resistance to other drugs in this group. Along with hypoglycemic agents to effect gipoholesterinemicheskoe effect and reduces blood trombogennye properties.

     Is inside after eating 1 to 2 times a day. Dose choose individually depending on the course of the disease and the effectiveness of therapy. Started with 0.0025 - 0.005 - 0.01 g (2, 5 - 5, 0 - 10.0 mg) a day. Sometimes dose had increased to 0,015, 0.02 grams per day.

     With the normalization of blood glucose establish supportive dose, usually 0,005 - 0.01 g, sometimes 0.0025 - 0.0075 g per day.

     If a daily dose of 0,015 - 0.02 g not work for 4 to 6 weeks, it should be assumed that the preparation for the patient does not go far enough; In these cases get to mix with glibenklamida biguanidami, but with little effect, a combination of Use of insulin.

     Contraindications and precautions such as the appointment butamida and other drugs in this group : prekomatoznoe and coma, ketoacidosis, child and adolescence, pregnancy and lactation, a violation of liver and kidney functions, radiation, allergic reactions to drugs and other sulfanilamidnye

     Product : pills to 0,005 grams (5 mg) in a package of 20 pieces.

     Storage : List B. In the dark spot.

Materials allowed to copy only with the active hyperlink to the handbook of medicines