GENTAMITSINA SULFAT (Gentamycini sulfas).

     Antibiotics, produtsiruemy Micromonospora purpurea; A mixture gentamitsinov S 1, S 2 and a 1.

     Synonyms : Garamitsin, Birocin, Celermicin, Cidomycin, Garamycin, Garasol, Gentabiotic, Gentalyn, Gentamin, Gentaplen, Gentocin, Geomycine, Lidogen, Miramycin, Quilagen, Rebofacin, Ribomicin, Sulgemicin, Sulmycin, Violyzen And p.

     White powder or porous mass kremovatym nuance. The easily soluble in water, virtually nerastvorim of alcohol.

     Refers to a group of Antibiotic aminoglikozidov. Has bacteriostatic action against many gram and gram microorganisms, including Protea, intestinal bacillus, and other salmonelloses force staphylococcus strains resistant to penicillin. Microbial resistance to gentamicin is growing slowly, but strains resistant to kanamycin and neomycin, also resistant to the antibiotic (cross resistance.) .

     The drug is rapidly absorbed by intramuscular introduction. After injecting therapeutic dose bactericidal concentration in the blood within a 8 - 12 pm

     Provided kidneys in high concentration unchanged.

     Gentamicin applied in a variety of infectious diseases caused by micro-organisms sensitive to it (with pneumonia, broncho, pleurisy, empieme, peritonitis, meningitis, septicemia, wound infections, etc.). The drug is effective when a urinary infection (chronic pyelonephritis, anesthetic, Urethritis), prostatitis.

     Doxycycline is a major means of combating severe purulent infection, particularly caused by resistant GRAM flora. In connection with a wide range of actions, gentamicin is often appointed to a mixed infection, as well as in cases where the cause has not been established (usually in combination with semi penitsillinami- ampicillin, karbenitsillinom etc.).

     In some cases, gentamicin is effective with a lack of other antibiotics.

     Applied gentamicin sulfate injection, intravenously (drip) and the local.

     In urinary tract infection single dose for adults and children over 14 years of age is 0.4 mg / kg daily 0.8-1, 2 mg / kg. Patients with severe infection during the daily dose may be increased to 3 mg / kg. In sepsis and other serious infections (peritonitis, Abscess light, etc.) single dose for adults and children over 14 years of age is 0.8 to 1 mg / kg daily 2, 4, 3, 2 mg / kg. The maximum daily dose of 5 mg / kg.

     Children early preparation designated only for health, with heavy infection. Daily dose for the newborn and infant is 2 to 5 mg / kg, 1 to 5 years - 1, 5, 3, 0 mg / kg, 6-14 - 3 mg / kg. The maximum daily intake for children of all ages, 5 mg / kg. The daily dose give 2 - 3 admission. The average duration of treatment 7 to 10 days. Intravenous injections produced within 2 to 3 days, then transferred to a local analgesic.

     For intramuscular use of gentamicin sulfate solution in the form of capsules or ex tempore solution prepared by adding powder in a bottle (or mass) 2 ml of sterile water for injection. Intravenous (drip) are only a ready solution in ampoules.

     In inflammatory respiratory diseases is also employed by inhalation (0.1% solution).

     In piodermii, folliculitis, abrasions and other designated ointment or cream containing gentamicin sulfate 0.1%. Cuticles affected areas of skin 2 to 3 times a day. The course of treatment 7-14 days.

     With conjunctivitis, keratitis and other infectious diseases of the eye fluid inflammatory eye drops (0.3% solution) 3 - 4 times a day.

     Doxycycline, like other antibiotiki- aminoglikozidy may have ototoksicheskoe and nefrotoksicheskoe effect.

     The drug is not suitable for pneumonia hearing nerve. It can not be appointed to other antibiotics, or have a big effect nefrotoksicheskoe. Pregnant appoint only emergencies.

     In light violations excretory functions kidney drug should be used with caution (in small doses). Patients uraemia and with serious kidney functions normally drug contraindications.

     Doxycycline has the ability to block nerve conduction and muscle could act like kurarepodobnym tools (see Kanamitsin).

     Method of issuance : powder (porous mass) of 0.08 g in vials; 4% solution in ampoules of 1 and 2 ml (40 or 80 mg in vials); 0.1% ointment in the tubes (10 or 15 grams); 0.3% solution (eye drops) in tube-drip.

     Storage : List B. In the dark spot.

     Gentatsikol (Gentacicolum). Plates of collagen sponge (see gemostaticheskaya collagen sponge), soaked in the solution gentamicin sulfate. One plate contains 0.0625 or 0.125 g gentamicin.

     Applied as a means of antisepsis infection in bone and soft tissues (osteomyelitis, abscesses, phlegmon, etc.), as well as for the prevention of complications after introducing operations on the bone.

     Preparation is a part of the plate or plates 1 - 2 (depending on the surface) of a plot to cause destruction after the surgical treatment. Plates gradually (over a 14-20 day) sutures.

     Contraindications see Gentamitsina sulfate.

     Storage : dry, the dark place at room temperature.

     Sponge antiseptics with gentamicin (Spongia antisepica cum Gentamycino). Dry porous mass of light amber in the form of plates the size of 50 x 50 and 60 x 90 mm.

     In one sponges contained 0.27 g g gentamicin sulfate, to 0.0024 g furatsilina and calcium chloride and gelatin food.

     Indications and contraindications, how to store Gentatsikol see.

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