GAMMA AMINOMASLYANAYA ACID (Gamma-aminobutyric acid)

     Chemical name : 4-acid Aminobutanovaya

     Description : The white crystalline powder with little bitter taste and unique smell. The easily soluble in water, very little of alcohol; PH 5% aqueous 6,5-7,5.

     Pharmacology : The drugs act-stimulating metabolism in the central nervous system, nootropic.

It is a major mediator involved in the processes of the central braking. Improves blood brain activates energy processes, increasing respiratory activity tissue, improves glucose utilization and disposal of toxic products exchange. GAMKergicheskimi interacts with specific receptors A and B types. Improves performance nerve processes in the brain, increases the productivity of thinking, improves memory, provides moderate stimulating, and antihypoxia protivosudorozhnoe effect.

Contributes to restore speech and motor functions after violations of cerebral circulation. Has moderate anti-hypertensive effect, reduces initially increased the severity of AD and hypertension symptoms (dizziness, insomnia), slightly urezhaet CHSS. For people with diabetes reduces blood glucose, in normal glycemia is often giperglikemiyu due glikogenolizom.

The concentration in the plasma reaches a peak after 60 min, then declined rapidly; After 24 h in plasma is not defined. The experimental data are poorly crosses the GEB. Malotoksichen.

     Application : The defeat brain vessels (atherosclerosis, hypertension, etc.) and cerebrovascular insufficiency and distsirkulyatornaya encephalopathy, a violation of memory, attention, speech, dizziness, headache, stroke and the effects of a brain trauma, alcoholic encephalopathy, polinevrit alcohol, mental retardation the children, dementia, infant cerebral palsy, endogenous depression dominated astenoipohondricheskih events, and difficulty thinking, syndromic Experiment (sea and air sickness).

     Contraindications : Giperchuvstvitelnost, childhood (up to 1 year), acute renal failure, pregnancy (I term).

     Application of pregnancy and breastfeeding : Protivopokazan I trimester of pregnancy.

     Side effects : Nausea, vomiting, insomnia, fluctuations AD (in the early days of treatment), neuralgia, hyperthermia, a sense of warmth.

     Networking : enhance the effect of drugs that have improved the function of central nervous system. Benzodiazipines potentsiruyut effect.

     Dosing and Administration : inside before eating. Adults - 1,5-3,75 g / day, children 1-3 years - 0,5-2 g / day, 4-6, 2-3 g / d, over 7 years to 3 grams per day. The daily dose divided into 3 admission; Rate of 2-3 weeks to 2-4 months.

Motion syndrome : adults - 0.5 g, 0.25 g children - three times a day for 3 days; To prevent in the same dose over the three days preceding the possibility motion.

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