FUZIDIN- NATRY (Fusidinum-natrium).

     Fuzidievoy acid sodium salt-antibiotic substances formed when pain grows Fusidium coccineum.

     Synonyms: Fuzidat sodium Fucidine, Fusidin, Ramycin, Sodium fusidicum.

     White to yellowish tinge crystalline powder. Soluble in water and alcohol.

     Chemically is tetratsiklicheskim connection with tsiklopentapergidrofenantrenovym nucleus. The same kernel is the basis of cardiac glycosides (see), steroid hormones (see), cholesterol.

     The activity of cardiac glycosides and hormones fuzidin no, but an effective means of resistance. Fuzidin operates on stafilokokki, meningokokki, gonokokki. For pneumococcus and streptococcal much less active. Stafilokokki resistant to penicillins, streptomycin, levomitsetinu, erythromycin and other antibiotics, sensitive to fuzidinu. The product is not active in school wand, salmonellosis, Protea and other gram of bacteria and fungi, and the simplest.

     When combined with other antibiotics fuzidina significant steps to strengthen its sensitive microorganisms.

     Fuzidin operates on microbial cell bakteriostaticheski. The mechanism is related to the rapid suppression of protein synthesis.

     Apply fuzidin- sodium inside. The product is not destroyed in the stomach and rapidly absorbed. Maximum concentrations in the blood are at 2 to 3 h and stored at therapeutic level in 24 hours When repeated moves may accumulate drug, and with long-term use can be cumulative.

     Fuzidin enters the lungs, liver, kidneys, blood exudation, bone, cartilage and connective tissue, skin, subcutaneous fat kletchaku; In smaller, but sufficient quantities for therapeutic effect, enters the spinal fluid (in the inflammatory processes in the brain tissue and skin).

     Report the body of mostly packaged in small quantities in the urine.

     Apply fuzidin- sodium for the treatment of diseases caused by resistant to other antibiotics stafilokokkami (Septicaemia, abscesses, phlegmon, abrasions, pneumonia, otity etc.), as well as infected burns and wounds.

     Because of the ability to infiltrate the bone tissue product successfully used to treat osteomielitov (see also Linkomitsina hydrochloride).

     Fuzidin- also use sodium in gonorrhoea, in the case of resistance to drugs cause penicillin group, or with the bad portability.

     In heavy over the disease and need long-term care, we recommend a combination of sodium fuzidin- polusinteticheskimi penicillins or tetratsiklinami that improves efficiency and prevents the emergence of resistant microorganisms.

     Assign fuzidin inside. Intramuscular injections because of a combination of local irritant (necrosis possible!) .

     Single dose for adults is usually 0.5 g daily, 1, 5 g (3 admission to the 8 hour intervals). In heavy infections appointed in the first 1 - 2 days to 2 to 3 grams a day, then reduce the dose (1, 5 g per day). The average duration of treatment 7 to 14 days, with osteomielite 2 - 3 weeks.

     Children nominate 40-60 mg / kg, while heavy during illness, and 80 mg / kg per day. Children under 1 year of the drug can be given in the form of suspension of syrup.

     When you receive fuzidin- sodium possible AI, pain in the abdomen, nausea, vomiting, diarrhoea, due mainly to the local irritant effect of the drug. To reduce the side effects of drug taking liquid food or milk. In rare cases, possible allergic reactions (redness oral mucosa and tonsils, skin rash, eosinophilia).

     Form release: fuzidin- sodium tablets to 0,125 and 0.25 grams of 20 pieces in banks orange glass.

     Storage: List B. In a dry, sheltered from the world scene, at room temperature.

     Apply fuzidina other drugs.

     Diethanolamine fuzidat (Diaethanolamini fusidas). Represents dietanolammonnievuyu fuzidievoy acid salt. White or white with a yellowish tinge powder, easily soluble in water.

     In action similar to fuzidin- sodium. Apply with heavy inflammatory diseases, diseases caused by resistant strains mnozhestvenno- stafilokokkov and other sensitive to fuzidinu microorganisms: pneumonia, sepsis, septic endocarditis, meningitis, osteomielite, treat soft tissue infections. You can assign patients with allergic reactions to penicillin and other antibiotics.

     The product introduced only intravenously. Solution to prepare just before use. Dissolve 0.25, or 0.5 g of drugs in 25 ml or 50 tsitratnofosfatnogo buffer, and then in isotonic sodium chloride solution (for children in 10% glucose solution) to the level of 250 or 500 ml. Concentration ready solution should not exceed 2 mg in 1 ml. Enter adults at speeds of 60 to 80 drops per minute, the children - 10 - 15 drops per minute. Daily dose for adults 1, 5 grams (maximum of 2 g) for children 20 to 40 mg / kg. The daily dose divided into 2 - 3 introduction. After injection in veins, introducing struyno 30-50 ml isotonic sodium chloride solution, or 5% glucose solution. Duration of treatment 3 to 5 days (if needed, and the absence of a local irritant to 7 days). Then designate the interior fuzidin- sodium tablets.

     The introduction of the drug can cause flebity, periflebity, allergic reactions. When expressed complications product repeal.

     Diethanolamine fuzidat contraindications with high content in the blood and increased protrombina individual sensitivity to the drug.

     Form release: in the hermetically ukuporennyh vials of 0.25, or 0.5 g drug application with one or two bottles tsitratno- phosphate buffer (2 mL vial in).

     Storage: List B. In a dry, sheltered from the world scene with a temperature higher than 10 C.

     Fuzidievaya acid (Acidum fusidicum; Fusidic acid). The white crystalline powder. Used inside of suspensions and externally in the form of gel.

     Indications for use inside the same as for fuzidin- sodium and diethanolamine fuzidata.

     Suspensions assign children (after eating) in the daily dose: under 1 year of age 60-80 mg / kg of 4 years and older-20-40 mg / kg. The daily dose divided into 3 admission. Duration of treatment 7 to 10 days, with a W-2 osteomielite weeks.

     Granules banks issued orange glass with a capacity of 150 ml containing 70 grams of grain (2, 5 g of the active substance).

     Storage: List B. In a dry, sheltered from the world scene at room temperature. The finished water slurry stored in the refrigerator (or at room temperature) no more than eight days.

     Gel <<Fuzidin>> 2% (Gelium <<Fusidinum>> 2%). Contains fuzidievoy acid 2 g, 3 g of zinc oxide, glycerol 20 ml, sodium carboxymethylcellulose, nipagin, water and 100 ml. Gel white or white with a yellowish tinge color.

     Assign gel structures in inflammatory diseases (surface follikulity, abrasions, piodermiya, impetigo, gidradenit superficial and limited burns, deep wounds, bruises, etc.) caused by susceptible pathogens fuzidinu.

     Gel cause of skin damaged by the removal of necrotic masses thin layer 2 times a day, with burns 2 to 3 times a week. The length of treatment depends on the form and severity of disease and averages 1 to 2 weeks.

     When treating drug may local irritant effect (redness, itching).

     Form release: in aluminium tubes of 15 g.

     Storage: B. list at room temperature.

     Gel <<Prefuzin>> (Gelium "Prefuzinum"). Contains fuzidievoy acid 2 g, prednisolone 0.5 g, 3 g of zinc oxide and other substances, distilled water and 100 g.

     Gel white or white with a yellowish tinge color.

     Apply externally with the usage of inflammatory skin diseases. Cause (adults) on the infection of skin thin layer 1 to 2 times a day.

     Apply in integrated therapy skin (eczema, Neurodermatitis etc.).

     In some cases, the treatment can skin redness, itching, allergic rash.

     Form release: in aluminium tubes of 15 g.

     Storage: B. list at room temperature.

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