FOZINOPRIL (Fosinopril).

     (4S) -4 - Tsiklogeksil-1- [R-[(S) -1-hydroxy metilpropoksi] (4-fenilbutil) fosfinil] acetyl] -L- propionat overcome.

     Issued in the form of sodium salt.

     Synonyms: Daynatsil, Monopril, Staril, Fozinorm, Monopril.

     White or not white crystalline powder. Soluble in water, methanol and ethanol.

     Has the balance of molecules in the L-overcome (like lizinoprilu), but fosfinilnuyu group (P = = O).

     Represents prolekarstvo, the body becomes active metabolite fozinoprilat.

     From other inhibitors fozinopril APF is the better ability to reduce blood levels endotelina, is a powerful factor and factor vazokonstriktornym remodelirovaniya receptacles.

     When you receive inside almost completely absorbed, bioavailability of approximately 40%, S-max 3 h, T? - 11.5 h; output from the urine and bile.

     Apply with arterial hypertension and chronic heart failure.

     As published in foreign literature data in patients post-heart attack miokarda, long (2) receipt fozinoprila led to a decline in the frequency of deaths and cases of severe heart failure.

     Assign inside of 0.01 g (10 mg) 1 every day. If necessary, gradually increase the dose to 0,02-0,04 g (20-40 mg) per day.

     Possible side effects: dispersion, cough, bronchospasm, angionevrotichesky swelling, pain in the chest, muscles and joints; Ortostaticheskaya hypotension, cardiac, arrhythmia, proteinuriya, oliguriya, fotosensibilizatsiya, skin itching.

     The product contraindications in pregnancy, breast-feeding and childhood.

     Form release: pills to 0.01 and 0.02 g (10 and 20 mg) (N. 10, 14, 20, 28).

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