FOSKARNET sodium (Foscarnet sodium).

     Digidroksifosfinkarbonovoy acid oxide trinatrievaya salt.

     Synonyms: Triapten, Foskavir, Triapten.

     The white crystalline powder. Soluble in water.

     Active against herpes viruses simple, wind pox, herpes zoster, Caplinskas and others.

     Blocks DNA polimerazu and HIV reverse transcriptase.

     Entering into poorly absorbed, bioavailability of 12-22%; With the introduction of intravenous C max -1-2 h; Kidney appears unchanged.

     Apply for infections resistant to viral infection in AIDS patients, as well as CYTOMEGALOVIRAL infection in patients with impaired immunity.

     Assign intravenously and externally.

     Intravenous use kapelno (5% glucose solution and isotonic sodium chloride solution in the ratio 1:1) with a viral infection in AIDS patients in the dose of 60 mg / kg every 8 hours or 90-120 mg / kg every 12 h during 18-21 days later, 90-120 mg / kg one time a day; while simple and herpes zoster - 40 mg / kg every 8 hours for 14-21 days.

     External appointed as cream.

     The product has patients; Moreover, can cause anemia, radiation, granulotsitopeniyu, thrombocytopenia, arrhythmia, a violation of brain circulation, neyrotoksicheskie effects (depression, psychosis, sleep violation, license, extrapyramidal disorder gemiparez, neuritis, encephalopathy, association, a violation hearing, a no, etc.), diarrhoeic phenomenon violation electroplating and mineral balance, breathing disorder, allergic reactions.

     Method of production: 2.4% solution for Infusion in vials of 250 and 500 ml; Cream.

     Storage: List B.

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