FLUVASTATIN (Fluvastatin).

     Sodium salt (±)-( 3R, 5S, 6E) -7-[3-(para-ftorfenil) -1 - izopropilindol-2- mud] -3,5 - dioksi-6- geptanoata.

     Synonym: Leskol, Lescol.

     First gipolipidemicheskih statinov (GMG- KoA- reductase inhibitors), obtained by synthetic.

     White or light yellow crystalline powder. Soluble in water, ethanol and methanol. Gigroskopichen.

     When you receive inside absorbed quickly and completely, bioavailability of approximately 20% ( "first pass effect" through the liver), T? h - 2-3; output mainly from faeces.

     Apply in primary giperholesterinemii (mainly type IIa and IIb), with the ineffectiveness of diet.

     Assign the inside, starting with 0,005 grams (5 mg) per day (before sleep), every 2 weeks dose can be increased to 0.02 g (20 mg) once in the first one day, then two times a day or to 0 , 04 g (40 mg) 1 every day.

     Effectively reduces total cholesterol and LDL.

     If necessary, reduce triglycerides appropriate use fluvastatin in combination with drugs anionoobmennyh resins (see Holestiramin). When combined with fibratami gipolipidemicheskoe of fluvastatina increasing, but between tricks and fluvastatina fibratov should observe a 12-hour break in order to avoid side effects.

     Possible side effects: dispersion, flatulence, insomnia, increased activity transaminaz blood myopathy.

     Contraindications of acute liver disease.

     Gemfibrozil, nicotine acid, erythromycin, immunosuppressants increase the risk miopatii.

     Form release: pills to 0.02 and 0.04 g (N. 28).

Materials allowed to copy only with the active hyperlink to the handbook of medicines