Flumazenil (flumazenil)

FLUMAZENIL (Flumazenil).
     Etil-8- fluoro-5, 6-digidro-5- metil-6- Ocso-4 H-imidazo [1,5-a] [1,4] benzodiazepin-3- karboksilat.
     Synonym: Aneksat, Anexate.
     White or almost white crystalline powder. Nerastvorim in water, soluble in weak acid water solution.
     As competition blokatorom BZ receptor eliminates central psychomotor effects of tranquilizers BZ: Neutralize snotvorno- sedative effect, helps restore breathing and consciousness when they overdose. However, it is against the internal agonisticheskoy BZ receptor activity and has protivosudorozhnoe effect.
     Apply to address the central (except protivosudorozhnogo) BZ effects of tranquilizers (including the withdrawal of anaesthesia, differential diagnosis of overdose).
     Assign intravenously (in 5% glucose solution or 0.9% sodium chloride solution): anesteziologicheskoy in practice-to 0.0002 g (0.2 mg) over 15, if necessary 0.0001 (0.1 mg) through 1 min to a total dose of 0,001 grams (1 mg); in intensive care in a dose-0.0003 g (0.3 mg); if necessary, repeat every 60 to a total dose of 0,002 grams (2 mg) .
     Possible side effects: blood tides to face, fear, heart (with the rapid introduction), convulsions (with epilepsy in history), benzodiazepine abstinence symptoms.
     Form release: 0.01% injection in the ampoule of 5 and 10 ml.
     Storage: List B.

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