FLUDARABIN (Fludarabin).

     9-? -D- [Arabinofuranozil-2- ftoradenin 5? (digidrofosfat)].

     Synonym: Fludara, Fludara.

     Cytostatics substance ribonukleotidnuyu reduktazu and inhibition of DNA and protein biosynthesis.

     Used to? - Cell leukemia, lymphoma nehodzhkinskoy (low MALIGNANCY), Mycobacterium mushroom, volosatokletochnom leukemia, lymphoma.

     Enter intravenously at 0,025 g (25 mg) for 1 m2 surface of the body daily for 5 days every 28 days.

     The solution for injection prepare ex tempore, entering into gm vial 2 ml of water for injection. The resulting solution razvodyat in isotonic solution (0.9%), water for injection: bolyusnogo for introduction in 10-20 ml; For acute-100 ml (within 30 min).

     Possible side effects: neutropenia, thrombocytopenia, anemia; Seldom-diarrhoeic phenomenon bleeding digestive problems, peripheral neuropathy.

     Contraindications: kidney failure, asthma haemolytic anaemia, pregnancy, breast-feeding.

     Form release: dried powders in vials of 0.05 g (50 mg).

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