FILGRASTIM (Filgrastim).

     Synonyms: Neypogen, Neupogen, Neupogen.

     Polypeptide (neglikolizirovanny), which contains 175 amino acid residues. Molecular mass of 8800 Dalton. (C845H1330N223O243S9).

     Getting through genetically engineering Escherichia coli. Contains gene granulotsitarnogo koloniestimuliruyuschego human factor.

     Granulotsitopoez promoted. Working with HEMATOPOIETIC receptors on the surface of cells, accelerates release of neutrophil pain and bone in the brain.

     Apply intravenously and subcutaneously.

     Doses set individually depending on the testimony of the seriousness and sensitivity of the patient to the drug.

     Treatment beginning no earlier than 24 hours after the end of chemotherapy. In tsitotoksicheskoy neutropenia imposed on 500,000 ED / kg / day, with transplants of bone marrow-1000000 ED / kg / day, with chronic and severe congenital neutropenia initial dose of 1.2 million ED / kg per day. Treatment continues to normalize neutrophil content in the blood (usually about two weeks).

     Side effects are rare. However, possible pain in the bones and muscles, skin redness and pain at the injection site, allergic reactions.

     Form release: injection syringe in tyubikah to 0.5; 1 and 1.6 ml (30000000 and 48000000 ED), and in vials PAs ml (30 million ED), and 1.6 mL (48,000 000 ED).

     For Infusion contents of the vial razvodyat in 5% glucose solution.

Materials allowed to copy only with the active hyperlink to the handbook of medicines