FIBRINOLIZIN (Fibrinolysinum).

     Fibrinolizin (or plazmin) is the enzyme from an activation of the blood plasminogen (profibrinolizina).

     Fibrinolizin (plazmin) is a physiological component of natural protivosvertyvayuschey system. At the core of the enzyme is its ability to dilute yarn fibrin. This effect is observed in vitro and in vivo. The nature of fibrinolizin be seen as proteinaza tissue (tissue proteolytic enzyme). Most expressed to fibrinolizina for fresh blood fibrin before retraktsii. In connection with these properties, fibrinolizin used for the treatment of diseases involving vnutrisosudistym deposition of fibrin clots and education embolism.

     Fibrinolizin profibrinolizina from human blood plasma in its fermentative activating trypsin. White hygroscopic powder. In izotonichesnom dilute solution of sodium chloride.

     Drug activity determined by biology, the ability to raise fresh Lysis standard bunch fibrinogena and expressed in units of (ED).

     Fibrinolizin apply in the case of fresh thrombosis (within 1-x days in coronary vascular thrombosis and cerebral vascular thrombosis and peripheral arterial branches, if not come gangrene; During the five-day 7 in the peripheral vein thrombosis). To increase the life of brain fibrinolizina efficiency decreases.

     Currently, the broad introduction of drugs streptokinase providing more permanent fibrinolitichesky effect with fewer side events; Fibrinolizinom are relatively rare.

     In therapeutic doses fibrinolizin not affect the process of phasing out blood, so must be applied in combination with anticoagulants (heparin). Heparin prevents further education embolism and ensure the effectiveness and safety therapy. Necessity of fibrinolizina with anticoagulants also determined that the available data, fibrinolizin can cause activation of blood coagulation; Moreover, since the introduction fibrinolizina may increase blood antifibrinoliticheskih properties.

     In a joint application with fibrinolizinom, Heparin give smaller doses than his own use. There may also be indirect actions BPH (Group dikumarina and fenilina); They apply immediately after fibrinolizina and geparina.

     Enter kapelno drug intravenously. Fibrinolizin located in a dry form in the vial, dissolve in sterile isotonic sodium chloride solution at a rate of 100-160 ED drug in 1 ml. Solutions prepared just before use, as when standing (in uslaviyah room temperature), they lose their potency. By solution fibrinolizina Heparin add an estimated 10,000 ED for every 20,000 ED fibrinolizina mixture and give veins from a speed of 10 to 15 drops per minute. With good portability to increase the speed of 15 to 20 drops per minute. Daily dose fibrinolizina is usually 20000 40000 - ED; The duration of 3 to 4 h (5000-8000 ED hour). To better define the optimal dose to explore plazminu resistance.

     After the introduction fibrinolizina with heparin continue to impose Heparin 40000 - 60000 ED day intravenously or intramuscularly within 2 to 3 days; Then gradually reduce the dose geparina and get to the reception inside antikoagulyantov indirect action.

     Apply fibrinolizin should be under the control of blood coagulation system. Admission fibrinolizina haemorrhage can be compounded because the enzyme is not only fibrin, but also other proteins involved in the mechanism of reduction of blood. Immediately after the introduction fibrinolizina determine the content protrombina (to be reduced to 40-30%), being the total collapse of blood (which should increase no more than 2 times), as well as the fibrinogena plasma (to be reduced, but not below 1 g / l).

     Fibrinolizin a protein and have antigenic properties; It can develop a response to nonspecific protein; Blood person pain during vein, which imposed solution, the pain for sternum and stomach, vomiting, increased body temperature, Urticaria and others to lift these developments will reduce the speed of the introduction of a more pronounced reaction, and it did stop. Apply also protivogistaminnye drugs.

     Contraindications to haemorrhagic diathesis, krovotecheniyah open wounds, stomach and duodenal ulcer disease diagnosis, nephrite, fibrinogenopenii, lung tuberculosis in acute form of radiation sickness. When brain defeat otnosntelnym contraindications is high blood pressure (systolic above 200 mm, diastolicheskoe 110-120 mm Art. Art.) .

     In ophthalmic practice fibrinolizin used in a vein thrombosis central retina and its branches, fresh vein central retina arteries, hypertension in front of the camera eye, vitreous body retina.

     To this end fibrinolizin appointed as ophthalmic solutions and films. The solution (the contents of the vial, dissolved in 5 ml of water for infections) enter under conjunctiva sklery or lower transition lap (after a local anestezni). Repeat injections through 1 - 2 days. The total number of injections from 3 to 10.

     In a film produced first local anesthesia (dikainom or other local anestetikom), and then to lay down a set of the film; Eye gaps closing at 30-60. Film lay day 1 every day. At treated 6-12 films.

     Form release: in the hermetically ukuporennyh vials containing at 10000; 20000; 30000 and 40000 fibrinolizina ED.

     Storage: at the temperature of up to + 2 - + 10 'C.

     For ophthalmic practice issued ampoule 300-400 and ED in the form of eye films (M embranulae ophtalmicae cum Fibrinolysini) containing 400 ED.

     Storage: in a dry place with a temperature of not more than + 10 'C.

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