EUFILLIN (Euphyllinum).

     Theophylline 1, 2-etilendiaminom. Teofillina content is about 80%, etilendiamina 20%.

     Synonyms: Aminofillin, Aminocardol, Aminophyllinum, Ammophyllin, Diaphyllin, Genophyllin, Methaphyllin, Neophyllin, Novphyllin, Synthophyllin, Theophyllamin, Theophylline ethylendiamine, etc.

     White or white with a yellowish white crystalline powder with a weak odor of ammonia. Soluble in water. Aqueous solutions (pH 9 0 9 7) prepare asepticheski.

     Effects eufillina due primarily teofillina content therein. Ethylenediamine increases skin activity and helps dissolve the drug. Molecular mechanism of eufillina largely similar to the mechanism of action teofillina.

     Important features are eufillina its solubility in water and the possibility of parenteral (intravenous) introduction.

     Like teofillinu, eufillin relaxing bronchial muscles, lowers resistance to blood vessels, increasing coronary vessels, lowers pressure in pulmonary arteries, increasing renal blood flow, has diureticheskoe effect associated primarily with lower kanaltsevoy reabsorbtsii; The increase is to bring water from urine and zlektrolitov, especially ions the sodium and chlorine.

     Preparation is critical constraint aggregation of platelets.

     Apply eufillin with bronchial asthma and bronhiolospazmah different etiology (mainly for kupirovapiya attacks); Hypertension in a small circle of blood, as well as in cardiac asthma, especially when accompanied by bronhiolospazmom attacks and violations of respiratory type Chain Stokes. It is also recommended for kupirovaniya cerebral vascular origin ateroskleroticheskogo crises and improve brain blood circulation, reduce swelling and pressure vnutricherepnogo brain in ischaemic stroke, and chronic brain circulatory failure. The product improves renal blood flow and can be used with appropriate evidence.

     Assign eufillin inside, the muscles, veins and mikroklizmah. Under the skin eufillina not impose solutions, as well as annoying tissue.

     Method introduction depends on the case: in acute bronchial asthma attacks and strokes entering intravenously, in less severe cases, intramuscularly or inside.

     Inside adults take for 0.15 grams after eating 1 to 3 times a day. Children inside are an estimated 7 to 10 mg / kg / day for 4 admission. Duration of treatment-from a few days to months.

     In the vein slowly introduce adults (over 4 minutes -6) on 0,12 0,24 g (10 mL of 5-2, 4% solution), which previously razvodyat 10-20 ml isotonic sodium chloride solution. If you have heart, dizziness, nausea, or slowing the speed of moving to a drip, which 10-20 mL of 2, 4% solution (0,24 0,48 g) razvodyat 100-150 ml isotonic sodium chloride solution; By introducing speed 30-50 drops per minute. When not in a vein type intramuscularly to 1 ml 24% solution.

     Eufillin parenteral transmission impose up to 3 times a day for no more than 14 days.

     Children entering intravenously for occasional dose of 2 to 3 mg / kg. The product is not recommended for children under 14 years (because of the potential side effects).

     You can assign eufillin rectally as mikroklizm. The dose for adults 10 to 20 mL of 2, 4% solution of 20-25 ml of warm water; Children less, in accordance with age.

     Higher doses eufillina adult inside, intramuscularly and rectally: single 0.5 g daily 1, 5 g; In vein: single 0.25 g daily 0.5 d.

     Higher doses for children inside, intramuscularly and rectally: single 7 mg / kg daily 15 mg / kg; Intravenous: single-3 mg / kg.

     When you receive eufillina inside (especially in the employment morning) may diarrhoeic phenomena associated with irritating to the drug; With the rapid introduction of intravenous possible dizziness, headaches, heart, nausea, vomiting, convulsions, a sharp reduction in AD.

     Intravenous introduction should be under the close supervision of indicators blood, breath, and the general feeling sick.

     With heightened sensitivity to possible etilendiaminu eksfoliativny dermatitis, feverish reaction and other side effects; When vnutrimyshechnom eufillina a possible place in the pain of making the introduction.

     In a rectal irritation can occur mucosa rectum.

     Application eufillina, especially intravenous counter with sharply reduced AD, paroxysmal tachycardia, arrhythmia, epilepsy. There should also be applied to heart failure drugs, particularly related to myocardial infarction, coronary insufficiency when there is a violation and a heart rhythm.

     Method of production: tablets to 0,015 g; 24% solution in ampoule for vnutrimyshechnogo introduction and 2, 4% solution in 10 ml ampoule for intravenous injection.

     Storage: List B. The well ukuporennoy packaging keeps from the world.

     R p. : Sol. E uphyllini 2, 4 ml 10%

     D.t.d. 3 in ampull.

     S. In veins (razvesti 20 ml isotonic sodium chloride solution).

     Enter slowly.

     R p. : Sol. E uphyllini 1 ml 24%

     D.t.d. N. in ampull 6.

     S. At 1 ml muscle in 1 - 2 times a day

     Rp. : E uphyllini 0.1

     UF hedrini hydrochloridi 0,025

     Sacchari 0.2

     M.f. pulv.

     D.t.d. N. in 12 caps. gel.

     S. At one capsule 2 - 3 times a day (with bronchial asthma)

     R p. : Ta b. E uphyllini 0.15

     D.t.d. N. PC

     S. At 1 tablet 1 to 3 times a day (after eating)

     Output abroad (Hungary) product "Diafillin 24% (Diaphyllinum) contains 1 1 ml vials of 24% solution (0.24 g) and 0.01 g eufillina anestezina; Enter only intramuscularly (intraglyutealno).

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