ESTRADIOL (Estradiol).

     Synonyms: Dermestril, Divigel, Klimara, Menorest, Oktodiol, Proginova, Estrozhel, Estrofem, Climara, Dermestril, Divigel, Estrofem, Menorest, Proginova.

     Acne hormone formed in the female body while estronom.

     The white crystalline powder. Almost nerastvorim water, it is difficult to dissolve in alcohol.

     According to the structure, physiological and pharmacological activity similar to estronu.

     In a esters (benzoata and lot) estradiol few breaks in the tissues of the body; He quickly and completely absorbed; Being in the liver biotransformation education estrona and estriola, provides insight from the ground in thin cancer, which re-absorbed, return slowly.

     Activity 1 mg estradiola benzoata with 10,000 ED.

     Apply in estrogennoy deficiency in the menopausal period and after gynecological operations, delayed sexual development in girls, girsutizme in polikistoza ovary syndrome, weakness generic activities for contraception, and prostate gland cancer.

     Assign the interior and local.

     Inside apply to 0,001-0,002 grams (1-2 mg) 1 hour per day (in prostate gland cancer three times a day).

     Gel cause of 0,5-1,5 g (0,5-1,5 estradiola mg) to the skin front wall of the abdomen or buttocks 1 every day, plaster-2 times a week.

     Possible side effects and contraindications common oestrogen drugs (see Estron).

     Method of production: tablets (Bean) to 0,002 grams (2 mg) (N 28); 0.015% intranasal spray in vials of 4.2 ml (150 ug / dose); 0.06% gel in box of 80 g and 0.1% in bags on the 0.5 and 1 g (N. 28, 91); transdermalny plaster on 9, 18 and 36 cm (2, 4 and 8 mg; 0,025; 0 05, and 0.1 mg / day, respectively), at 12.5 cm (3.9 mg) and plaster fort to 25 cm (7.8 mg).

Materials allowed to copy only with the active hyperlink to the handbook of medicines