ERITROMITSIN (Erythromycinum).

     Erythromycin is an antibacterial substance produced Streptomyces erythreus or other related pathogens.

     Refers to a group makrolidov-compounds containing molecules in makrotsiklicheskoe laktonnoe ring. This group includes oleandomitsin.

     Synonyms: Eritrocina, Ermycin, Erycinum, Erythran, Erythrocin, Erythromycin, Etromycin, Ilotycin, Lubomycin, Pantomicina and e p.

     A white crystalline powder odourless, bitter taste. Few soluble in water, easy-to alcohol. Gigroskopichen. In theory, 1 mg contains 1000 ED; Little activity comes with at least 900 ED 1 mg.

     On spectrum antimicrobial action erythromycin close to penicillins. He is active against gram and gram microorganisms (stafilokokki, pnevmokokki, streptococci, gonokokki, meningokokki). There are also a number of gram bacteria brutsell, rikketsy, trachoma pathogens and syphilis. Poor or not a gram of most bacteria, typically, small and medium viruses, fungi.

     Erythromycin transferred patients better than penicillins, and can be used in allergy to penicillins.

     In therapeutic doses of erythromycin are bakteriostaticheski. Antibiotic Resistance to develop rapidly, with the other group of antibiotics makrolidov (oleandomitsin) is a cross-resistance. When combined application with streptomycin, and tetratsiklinami sulfanilamidami strengthened action erythromycin.

     Apply erythromycin with pneumonia, pnevmoplevritah, bronhoektaticheskoy stage of the disease and deterioration and other infectious diseases in the lungs, caused by sensitive to the antibiotic microorganisms; When septic condition, rozhistom infected, mastitis, osteomielite, peritonitis, eight media and other structures inflammatory processes. He also appointed syphilis patients with liver antibiotics penicillin group. Through erythromycin does not cross the blood-brain barrier penetrating, if meningitis is not appointed.

     Local (in the form of ointment) used erythromycin gnoynichkovyh defeat in the skin of infected wounds, straight, etc., as well as conjunctivitis, blefarite, trachoma.

     In severe forms of infectious diseases, when receiving the drug inside ineffectual or not, resort to a soluble form of intravenous erythromycin, erythromycin phosphate.

     To receive inside erythromycin appointed as tablets or capsules. An adult dose of 0.25 g machines, with heavy disease - 0.5 was accepted every 4 to 6 hours for 1 - 1 5 h before the meal.

     The highest single dose for adults: interior 0.5 g, 2 grams daily for children under 14 years of age shall designate a daily dose of 20 to 40 mg / kg (4 admission), over 14 years - in dose for adults.

     Adverse events in the treatment eritramitsinom are relatively rare (nausea, vomiting, diarrhoea). In a lengthy application possible violations of liver function (jaundice). In some cases, there may be a heightened sensitivity to the drug, with the advent of allergic reactions.

     In a lengthy application erythromycin possible development of resistance of microorganisms.

     The product contraindications to individual high degree of sensitivity to it and severe violations of liver function.

     Erythromycin improves concentration in the blood plasma karbamazepina, teofillina and makes them toxic effects (nausea, vomiting, etc.).

     Method of production: tablets of 0,1 and 0,25 g; Tablets of 0.1 and 0.25 grams of soluble coating Guatemala (Tabulettae Erythromycini enterosolubiles 0.1 e t 0.25); Ointment 1%.

     Under the title <Eric> issued in the form of Hungarian drug erythromycin glanuly concluded in capsules, containing 250 mg drug. Capsules dissolved only by ingestion bowel.

     Storage: List B. In sheltered from the world scene with a temperature higher than  + 20C.

     Ointment eritromitsinovaya (Unguentum Erythromycini). Contains 1 g 10000 ED erythromycin.

     Ointment yellow.

     Gnoynichkovyh apply in treating skin diseases, infected wounds, bedsores, burns II and III level, trophic ulcers. Ointment cause of the infection of 2 - 3 times a day, with burns 2 to 3 times a week.

     With an eye ointment diseases in the number of 0.2 - 0.3 grams for the lower or upper age 3 times a day, with trachoma 4 - 5 times a day.

     The length of treatment depends on the severity of the disease and during therapy and judging. The average duration of treatment is 1 5-2 months. The course of treatment for trachoma-to 4 months.

     Ointment generally well tolerated by, but may moderate irritant effects.

     Form of: the aluminum tubes to 3; 7; 10; of 15 and 30 g.

     Storage: B. list at room temperature.

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