ENOKSAPARIN sodium (sodium Enoxaparine).

     Synonyms: Kleksan, Klexan, Lovenox.

     The product nizkomolekulyarnogo geparina with molecular weight of about 4500 Dalton.

     Contact with antitrombinom III (endogenous inhibitor collapse blood) enoksaparin sodium potentsiruet its negative effect on education and activity factors Ha, which in turn leads to lower educational thrombin. There enoksiparina sodium ratio antitromboticheskoy and antikoaguliruyuschey activity (activity antifaktorov Ha and II a) is approximately 3:1, compared to 1:1 in nefraktsionirovannogo geparina.

     In subcutaneous introduction rapidly and completely absorbed, C max, as well as peak inhibition activity of factor Ha been through 3-5 h; T? 47-h; return the kidneys.

     Use of surgical and orthopaedic practice for the prevention tromboemboly; In deep vein thrombosis, pulmonary artery embolism, acute coronary insufficiency, and to prevent giperkoagulyatsii in extracorporal circulation during hemodialysis.

     According to data published overseas, in patients with unstable stenocardia and Myocardial Infarction enoksaparin sodium in combination with acetylsalicylic acid in short-term use (14-30 days) exceeded nefraktsionirovanny Heparin (a combination of two acetylsalicylic acid) on the ability to reduce the frequency of attacks stenocardia, re-infarction heart attacks, hospitalizations, myocardial revascularization, and other complications.

     Enter subcutaneously (in peredne- zadnelateralnuyu area or abdominal wall) and sometimes intravenously.

     To prevent deep vein thrombosis and pulmonary artery embolism in the surgical intervention with moderate and high risk, respectively, to enter 2000 and 4000 IU (0.02 and 0.04 g) for 2 h before the surgery, and then one every day 7-10 g; therapeutic sick ME-4000 (0.04 g) one time a day during 6-14 days.

     When treating razvivshegosya deep vein thrombosis and pulmonary artery embolism impose 150 IU / kg (1.5 mg / kg) 1 hour a day for at least five days to transfer to the proximity BPH.

     In volatile stenocardia and heart attack without myocardial points Q impose 100 IU / kg (1 mg / kg), 2 times a day for 2-8 days (the first subcutaneous injections may be preceded by intravenous drug dose to 0.03 g (30 mg) .

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