EBASTIN (Ebastine).

     4'- Butil-4- tert-[4 - (difenilmetoksi) piperidino] butiroferon.

    Synonym: Kestin, Kestine.

    Derivative butirofenona (see Galoperidol); A structural (and pharmacological) similar to PEP (see).

     N1- gistaminovyh receptor blockers are long-lasting. There has antiholinergicheskoy activity.

     There has expressed sedative effect.

     When you receive inside quickly absorbed, C max is 2,6-4 h, T? - 15-19 hr not penetrate through cross the blood-brain barrier; under intense biotransformation in the liver and intestine with the formation of the active metabolite karebastina, appears mainly kidneys.

     Apply (other N1- gistaminovyh receptor blockers) with allergic rhinitis and conjunctivitis, chronic hives.

     Accepted inside (regardless of when meals) to 0,01-0,02 g (adults) 1 every day.

     Possible side effects: headache, drowsiness, drought in the mouth, seldom - dispersion, insomnia, asthenic syndrome.

     The product contraindications expressed in liver failure, pregnancy and breast feeding, under the age of 12 (not reviewed).

     Form release: pills to 0.01 g (10 mg) (N 10).

     Storage: List B.

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