DROTAVERIN (Drotaverine)

     Chemical name : 1-[3,4 - Dietoksifenil) methylene] -6,7 - dietoksi-1, 2,3,4 - tetragidroizohinolin (as hydrochloride)

     Description : Kristallichesky powder light amber, odourless. Mg in water and alcohol.

     Pharmacology : The drugs-spasmolytic effect, miotropnoe, salts, anti-hypertensive.

Impact of ionized calcium in active gladkomyshechnye cells through inhibition of intracellular accumulation and fosfodiesterazy tsAMF. Quickly and completely absorbed in the digestive tract. When ingestion bioavailability is close to 100%, a period poluabsorbtsii-12 min. Evenly divided on the fabric, enters gladkomyshechnye cells. Excreted kidneys.

Manifestly, and the long-term increases the smooth muscles of internal organs and vessels, reduces AD increases minute of the heart. Virtually no effect on the autonomic nerves and not into the central nervous system.

     Application : Spasm smooth muscles of internal organs (cardio and pilorospazm), chronic gastroduodenit, gastric ulcer disease and gastrointestinal cancer, zhelchnokamennaya disease (renal colic), chronic cholecystitis, postholetsistektomichesky syndrome, biliary tract gipermotornaya psoriasis, psoriasis spastic bowel, intestinal colic because of the delay after gas operations, colitis, proktit, tenezmy, flatulence, ìî÷åêàìåííàÿ disease (renal colic), pielit, causes stroke, coronary and peripheral arteries, reducing the need to reduce and remove causes uterine cervix during childbirth, causes the smooth muscles during the instrumental interference.

     Contraindications : Giperchuvstvitelnost, glaucoma.

     Restrictions apply to : Enlarged prostate gland expressed in atherosclerotic coronary arteries.

     Side Effects : The sense of warmth, dizziness, adults, hypotension, palpitation, sweating (often with a parenteral), allergic dermatitis.

     Networking : Usilivaet (especially w / a) the effect of other spazmolitikov (including holinoblokatorov m), hypotension, caused tricyclic antidepressants, quinidine, novokainamidom. Reliability eliminate diseases increases phenobarbital. Decreases spazmogennuyu activity morphine ANTIPARKINSONISM properties of levodopa.

     Overdosing : AV blockade, cardiac arrest, respiratory paralysis center.

     Dosing and Administration : The inside-to 0,04-0,08 g 2-3 times a day. V / m, p / c, 2-4 Jr. 1-3 times a day to remove cramps in / to slow to 2-4 ml. Children under 6 years of 0,01-0,02 g 1-2 times per day, children 6-12 years, 0.02 g 1-2 times daily.

Materials allowed to copy only with the active hyperlink to the handbook of medicines