DROPERIDOL (Droperidolum). 1-(1-[3-parameter Ftorbenzoil) propyl] -1, 2, 3, 6-tetragidro-4- piridil) 2-benzimidazolinon.

     Synonyms : Dehydrobenzperidol, Dridol, Droleptan, Droperidol, Inapsin, Sintodril and others.

     Light Cream crystalline powder. Storage in air and light yellow.

     Almost nerastvorim in the water, little is soluble in alcohol.

     Neuroleptic butirofenonov funds from the group. Provides quick, strong, but short of. The effect of the introduction of non-manifested through 2 - 5 minutes, reaching a maximum of about 20 - 30 minutes. Step depending on the dose until 2 to 3 hours

     The preparation of potentsiruet analgeticheskih and hypnotics funds. Has protivoshokovym and antiemetics properties. Has a adrenoliticheskoe-operation; Central dofamine blocking receptors; No holinoliticheskoy activity. Lowers AD has antiaritmichesky effect. Has strong kataleptogennoy activity.

     In psychiatric practice Droperidol used in psychomotor anxiety, hallucinations. Mostly used in anaesthetics practice for neyroleptanalgezii usually in combination with fentanyl (see) or other analgetikami.

     Joint application droperidola incidence and causes rapid neurotic and analgesic effect, sleeping state, muscle relaxation, warns shock has protivorvotnoe effect. Patients easily go out of neurotic analgezii.

     Droperidol applied for sedation, in the operation and aftercare period. Using endotrahealnom with anaesthesia, and the operations of local anesthesia.

     Enter Droperidol under the skin intramuscularly and intravenously.

     When sedation and usually impose neyroleptanalgezii Droperidol intramuscularly for 30 to 45 minutes before the operation dose of 2, 5, 5 mg (1 - 2 mL 0.25% solution), together with 0.05-0.1 mg (1 - 2 mL 0 , 005% solution) exhibited or 20 mg (1 ml 2% solution) promedola. 0 tent impose 0.5 mg (0.5 mL 0.1% solution) or atropine metatsina.

     In endotrahealnom anaesthesia Droperidol first imposed at the rate of 2, 5 mg per 5 kg of body weight with the incidence rate of 0.05 mg per 5 kg of body weight (or 1 ml combined talamonala 5 kg body weight). Then, the introduction of anaesthesia used neingalyatsnonnye anaesthetics, oxybutyrate sodium or tranquilizers (diazepam, sibazon). Anaesthesia support nitrous oxide with oxygen in the ratio of 1:1 or 3:1. During the operation every 15 or 30 minutes when the signs of an easing of introducing more fentanyl on 0.05-0.1 mg (1 - 2 mL). In the event of a cardiac arrhythmia impose more Droperidol (2, 5, 5 mg).

     For muscle apply muscle.

     During droperidola injections and the patient exhibited breathing a mixture of oxygen with nitrogen oxide (1:1).

     With local anesthesia impose Droperidol (slow) intravenously or intramuscularly at a rate of 0.1 mg / kg. After 8-10 minutes after the end of droperidola slow in introducing non-test dose of fentanyl (0,005 mg = 0.1 ml 0.005% solution). Test dose necessary for the identification of possible increased chuvstvitelnostn, expressed sharp aetiology, difficulty breathing, the crunch in the chest. With good endurance operations performed under local anaesthetic and injected (within 2 min) every 6 to 8 minutes before the 0,005 - 0.01 - 0.015 mg fentanyl (depending on the patient's body mass), and every 30-40 minutes at 0.09 mg / kg droperidola.

     To facilitate more, reducing nausea and vomiting in the aftercare period if necessary intramuscularly impose 2 5 5 mg droperidola and 0.05-0.1 mg exhibited.

     Neyroleptanalgeziya droperidolom with fentanyl was used to combat pain and shock at heart attacks and in patients with severe stroke strokes. Enter slowly in the non-2, 5 - 5 mg (1 - 2 mL) droperidola and 0.05-0.1 mg (1 - 2 ml) exhibited, divorced 20-40 ml 5% glucose solution. Positive results were also swelling in the lungs.

     For edema PNDS crises Droperidol struyno injected dose of 0.1 mg / kg (usually 2 ml 0.25% solution). Preparation is the most effective for crises in patients with hypertension A stage II disease and senile patients.

     To prepare for the painful instrumental diagnostic procedures imposed by the half hour intravenous 2 5 5 mg droperidola.

     Using droperidola should carefully monitor blood circulation and respiration. Large doses may cause a reduction AD and respiratory depression. Step muscle Ward, analgetikov, the drug significantly increased.

     For patients, and patients with insulin corticosteroid, with the express atherosclerosis, violations conductivity cardiac muscles, cardiovascular system diseases being decompensation caution.

     Droperidol and fentanyl applied only in the United States.

     Droperidol is contraindicated in extrapiramidale violations, as well as those who received long-term funds hypotensive (possibly sharp fall AD). In combination with fentanyl is not suitable for a cross-section deliveries as a result of oppression respiratory centre fruit.

     Product droperidola : 0.25% solution in ampoules of 5 and 10 ml (12, 5 or 25 mg; 2, 5 mg in 1 mL).

     Storage : List B. In dry, the dark place at a temperature of 5 + O to C.

     Talamonal (Thalamonal) *. Combined foreign product. Contains 1 to 2 ml, 5 mg and 0.05 mg droperidola exhibited.

     Using for neyroleptanalgezii and in other cases, the separation of the two drugs.

     Product : in 2 ml ampoules and bottles (for injection) to 10 ml.

     Storage : List A.

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