DOKSITSIKLINA HYDROCHLORIDE (Doxycyclini hydrochloridum). 6-Dezoksi-5- oksitetratsiklina hydrochloride.

     Semi oksitetratsiklina derivative.

     Synonyms : Apo- Doxey, Bassado, Vibramitsin, Dovitsin, Doksal, Doksibene, Doksidar, Doksilan, Doksilin, Dokst, Medomitsin, Monoklin, Novo Doksilin, Tetradoks, Etidoksin, Yunidoks solyutab, Abadox, Apo-Doxy, Bassado, Biociclina, Biostar , Dovicin, Doxacin, Doxal, Doxigram, Doxilen, Doximocyn, Doxipan, Doxybene, Doxycycline, Doxydar, Doxylan, Doxylin, Doxt, Ethidoxin, Extraciclina, Isodox, Lampodox, Medomicin, Micromicin, Minidox, Monocein, Monocline, Novacyclin, Novo-Doxyline , Saramicina, Sincromycin, Tetradox, Unidox silutab, Vibrabiotic, Vibracina, Vibradoxil, Vibramycin and others.

     The yellow crystalline powder. Slowly soluble in 3 parts water. Theoretical activity in 870 ED 1 mg.

     Like other tetracycline a wide range of antimicrobial action. Active against most gram and gram microorganisms, including those resistant to other antibiotics (except tetracycline).

     Like other tetracycline, doxycycline has also rickettsiae, mycoplasmas, agents psittacosis, fever, trachoma and some protozoa. It affects the majority of strains Protea, sinegnoynuyu wand, mushrooms, small and medium-sized viruses.

     The drug is rapidly absorbed slowly out from the body; Depending on the input dose therapeutic concentration in the blood is maintained for a period of 18-24 hours With a possible repeat drug accumulation. Preparation is well into the organs and tissues, not in spinal fluid. Write a considerable number of urine in a small amount of faeces.

     Indications for use are the same as for other tetracycline; Especially in case of acute and chronic bronchitis, pneumonia, pleurisy, urinary tract infections, gonorrhoea. There is evidence of the effectiveness of the drug in the face skin.

     Assign doxycycline hydrochloride adults and children over 8 years inside and intravenously.

     Both ways introduction daily intake for adults is one day treat 0.2 g; Enter one day or 0.1 g in 12 hours In the following days, apply in daily dose 0.1 g (1 per day).

     When heavy during infection, daily intake is in one day and the following days, 0.2 g.

     Children 8 to 12 years of preparation designate dose 4 mg / kg / day for 1 day of treatment and 2 mg / kg in the coming days (4 mg / kg, with severe infections over), children over 12 years in the dose for adults .

     Inside take doxycycline hydrochloride after eating (to avoid), mucous membrane irritation of the stomach), squeezed by large amounts of water. It should not be zapivat milk and take a medication containing ions of calcium, magnesium, aluminum (calcium chloride, antatsidy etc.).

     Intravenous designate doxycycline hydrochloride with severe forms of chronic septic disease, which need to quickly establish a high concentration of the antibiotic in the blood, and if the receiving drugs inside difficult or poorly transferred patients.

     Intravenous drip type. Solution to prepare, just before the introduction, breeding contents 1 - 2 vials (0.1 - 0.2 g) in isotonic sodium chloride solution, or 5% glucose solution. The concentration of drug in solution for infusions should not exceed 1 mg / ml. Infusion duration, depending on the dose (0.1 or 0.2 g), 1 to 2 h at a speed of 60 to 80 drops per minute. During Infusion solutions should be protected from light (solar and artificial). The duration of treatment with intravenous is 3 to 5 days, with good endurance to 7 days, and moving (if necessary) to receive the drug inside (in the form of capsules or tablets). When taken drugs inside depending on the course and severity of disease treatment is 7 - 10 days.

     When treating gonorrhea doxycycline appoint one of the following schemes : acute patients neoslozhennym get in exchange dose of 0.5 g (1 st reception - 0.3 g, the next two installments on 0.1 g every 6 h); When complications in the form of gonorrhea, exchange dose of antibiotic (0.8 - 0.9 g) divided by 6 to 7 introductions (0,3 g of the 1 st reception of 0.1 g every 6 h for the next 5 - 6).

     Possible side effects such as the application of other tetracycline, but they are relatively less developed. Caution must be exercised when disturbed kidney and liver function (possible accumulation of the drug and gepatotoksicheskoe high concentrations). The drug causes photosensitization.

     In hepatic kidney failure drug is used by the functional state of the liver and kidneys. In the case of allergic reactions to desensibiliziruyuschuyu therapy.

     To prevent development kandidozov, while doxycycline hydrochloride encouraged to nominate nystatin or levorin.

     Sodium bicarbonate, antatsidy containing aluminum salts, bismuth, magnesium, iron preparations, carbamazepine, gidantoiny reduce drug intake and the level of doxycycline in plasma.

     Indications are the same as for other tetracycline (see, for example, Metatsiklina hydrochloride).

     Method of issuance : capsules of 0.05 and 0.1 g; The tablets, coated on 0.1 g; Dried powder (or porous mass) in ampoules of 0.1 g.

     Storage : List B. In dry, the dark place at room temperature

     In Poland, doxycycline (called "Vibramitsin") issued capsules to 0.1 g and a mist (syrup), containing 1 ml of 0.01 g doxycycline. One teaspoonful (5 ml) contains 50 mg of active substance. Available in bottles of 20 ml.

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