DOKSORUBITSINA HYDROCHLORIDE (Doxorubicini hydrochloridum).

     Antratsiklinovogo antitumor antibiotic series. According to the chemical structure similar to rubomitsinu (see). Is only that the situation instead of a 14 atsetilnoy group SOSNz oksiatsetilnuyu COCH 2 OH, ie as can be seen oksirubomitsin.

     Synonyms: Adriablastin, Adriamitsin, Aksidokso, Blastotsin, Doksolem, Doksorubifer, Rastotsin, Adriamicin, Adriblastin, Aksidoxo, Doxolem, Doxorubicin, Doxorubiferum, Farmiblastina, Hydroxydaunomycin, Rastocin.

     Red crystalline powder or porous mass. Moderately soluble in water, nerastvorim in alcohol.

     Doxorubicin is very protivoleykoznoy and antitumor activity. On mechanism of close to rubomitsinu, capable interkalirovat DNA of cells. Provides negative impact on the blood. Has immune activity.

     Apply doxorubicin in breast cancer, soft tissue sarcoma, osteogennoy sarcoma, Ewing tumors, cancers lung, lymphosarcoma, cancer of the ovaries, ploskokletochnyh illustrate various localization, bladder cancer, Wilms tumor, thyroid cancer, acute leukemia, chlamydia.

     Enter only intravenously. Assign one of the following schemes: a) to 30 mg / m 2 1 surface of the body each day during the three days; The intervals between courses of four weeks; B) 60 mg / m 2 1 once every 3 weeks; C) on ZOmg / m 2 1 Weekly (1 st, 8 th and 15 th days of course). Courses repeated every 3 weeks.

     The total dose of doxorubicin should not exceed 550 mg / m 2.

     For patients who received prior radiation therapy for lung and Medical area, the sum of doxorubicin dose should not exceed 400 mg / m 2.

     For intravenous dissolve the contents of the vial with doxorubicin (10 mg) in 5 ml isotonic sodium chloride solution.

     Using doxorubicin possible leukopenia and thrombocytopenia, disease, nausea and vomiting (immediately after preparation), white (reversible), allergic reactions, subcutaneous adipose tissue necrosis by ingestion drug under the skin, flebity.

     The use of doxorubicin should be under strict control of blood.

     One of the salient features of poison doxorubicin is a kardiotoksicheskoe effect.

     In drug treatment can develop cardiomyopathy, pain in heart rhythm violations, cardiac failure, lowering blood pressure. With heavy heart rhythm irregularities or long deficiency, doxorubicin treatment should cease immediately.

     The use of doxorubicin counter severe violations of the liver and kidneys, radiation (less than 3, 5 x 10 9 / L), thrombocytopenia (less than 12 x 10 9 / L), heavy heart related diseases (myocarditis, heart attacks miokarda, significant violations rhythm), krovotecheniyah , tuberculosis, beremennnosti, gastric ulcer disease and stomach ulcer. It should appoint a drug prior months after the previous one other chemotherapy drugs

     Form release: to 0.01 g (10 mg) in 10 ml vials capacity in the package of 50 vials.

     Storage: List A. In a dry, sheltered from the world scene, with a temperature of not more than+  5 C.

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