DOKSEPIN (Doxepine).

     3-Dibenzo [b, e] oksepin-11 (6 N) - iliden-N, N - dimethyl propanamina hydrochloride.

    

     Synonym : Sinekvan, Sinequan.

     The white crystalline powder. Well soluble in water, in the worse-alcohol and chloroform.

     Anksioliticheskimi with antidepressant properties and sedatives. Has antiserotoninovym, cholinolytic, protivogistaminnym and protivoyazvenyym action.

     Quickly and completely absorbed in the digestive tract, T1 / 2 at 28-52 h; Pobvergaetsya biotransformation in the liver to the active metabolite dimetildoksepina education, provides kidney.

     Applied with depression and neurotic condition, alcoholism with anxiety and concern; In medical therapy with duodenal ulcers gut.

     Assign inside. Initial daily intake for adults 0,075 g (75 mg) in the 1-3 entry, if necessary, it can be increased to 0.3 grams a day, older appoint 0,03-0,05 g (30-50 mg) daily, children - 0.5 mg / kg per day. The therapeutic effect was usually after 2-3 weeks after the start of treatment.

     Possible side effects : neuralgia, the delay urination, visual, drowsiness, hallucinations, ataxy, extrapiramidale disorder, arterial hypotension, allergic reactions, etc.

     The drug is contraindicated in atrioventrikulyarnyh blockade, zakrytougolnoy glaucoma, the isolationist prostate gland.

     If long-term care is not recommended sudden stop because of the risk of cancellation syndrome; Should refrain from activities that require high speed of mental and physical reactions.

     Do not appoint doksepin with MAO inhibitors; During treatment is not allowed alcohol.

     Product : Capsule to 0.01 and 0.025 g (10 and 20 mg) (N. 15.30).

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines