DOKSAZOZIN (Doxazosin).

     1-(4-Amino-6, 7-dimetoksi-2- hinazolinil) -4-[(1,4-d benzodioksan-2-) - carbonyl] piperazine.

     Available in a monometansulfonata (mezilata).

     Synonyms : Cardura, Tonokardin, Cardura, Tonocardin.

     Powder white. The easily soluble in dimetilsulfokside, soluble in dimethylformamide and hard-water, ethanol, methanol and acetone.

     The structure and action close to prazozinu. Contains benzodioksanovy substituent in certain synthetic? - Adrenoblokatorov (see Pirroksan, Butiroksan).

     Is electoral blokatorom postsinapticheskih? 1-adrenoreceptor. Compared with prazozinom has a prolonged effect.

     Quickly and almost completely absorbed, bioavailability of approximately 65%, due to the effect of "first pass" through the liver, C max for 2-3 h, T? - 19-22 h; devoted primarily with feces in the form of metabolites.

     Applied with arterial hypertension and isolationist prostate gland.

     Assign the inside, starting with 0,001 g (1 mg), 1 per day. Then gradually increase the dose if necessary to 0,004-0,008 grams (4-8 mg) a day.

     The maximum daily dose of arterial hypertension 0,016 g (16 mg).

     Possible side effects, precautions and contraindications are basically the same as when applying prazozina.

     An cases of fog, cholestasis, yellows, sometimes impotence admission doksazozina.

     Product : pills to 0,001; 0,002; 0,004 and 0,008 grams (1; 2; 4; , And 8 mg) (N. 10, 20, 30).

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