Dorzolamid (dorzolamide)


DORZOLAMID (Dorzolamide).
     4 - (Etilamino) -5,6-N-methyl digidro-6- tieno [2,3-b] - tiopiran-2- sulfonamid-7, 7-dioxide (hydrochloride).
     Synonym : Trusopt, Trusopt.
     White or not white crystalline powder. Mg in the water, it is difficult to dissolve in methanol and ethanol.
     On chemical structure has similarities with diakarbom and gidrohlortiazidom.
     It has expressed the ability to block karboangidrazu tsiliarnom body in the eye and effectively reduces the inner pressure (mainly by reducing secretions watery moisture), in patients with glaucoma local application in the form of eye drops.
     Assign with different types of open glaucoma. By reducing the inner pressure is usually not losing? - Adrenoblokatoram (timololu, betaksololu). Moved better than pilocarpine (no mioza).
     Enter one drop in konyunktivalny bag patient eye 2-3 times a day. The maximum anti-hypertensive effect develops after 2 h after instillyatsii and maintained for a period of 12 h.
     An trusopta in combination with eye drops? - Adrenoblokatorov (timololom); Sometimes there has been increasing pressure to reduce inner.
     In conjunction with several local ophthalmic drugs each set with an interval of 10 minutes.
     Drops trusopta (like other antiglaukomatoznye eye drops) should be under the control of systematic inner pressure. Consideration must be given to an individual reaction (on the effectiveness and transferability).
     When using small droplets trusopta may itch, burning and tingling in their eyes, a short fog, the bitterness in the mouth, in some cases, conjunctivitis, Blepharitis, allergic reactions (skin rash), parestezii.
     The drug is contraindicated in severe renal failure, gipohloremicheskom disorders, pregnancy, breast-feeding, infant.
     As in the case of other LS, thus elevated individual sensitivity.
     Product : 2% solution in flakonah- looks to 5 ml.
     Kosopt (Cosopt). Eye drops containing 2% solution dorzolamida and 0.5% solution timolola (in vials of 5 ml).

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