DORNAZA ALFA (Dornase alfa)

     Synonym : Pulmozim, Pulmozyme

     Description : Rekombinantnaya dezoksiribonukleaza rights are being modified ovary cells of Chinese homyachkov. Glikoprotein consists of 260 amino acids, the molecular mass of 37 kD.

     Pharmacology : The drugs act-mukoliticheskoe.

In inhalation introduction destroys leukocyte DNA contained in sputum with pulmonary infection. Decreases viscosity and facilitate the provision of a secret, improves the function of external breathing. Reduces the risk of deterioration of lung infections.

With a 2.5 mg inhalation concentration in sputum in 15 minutes to 3 µ g / ml, and then it gradually declined and by the end of 2 h at 0.6 ug / ml. Even lengthy application large doses (10 mg) is not greater DNKaznoy activity in the serum.

     Application : Dilution and facilitate derogation sputum in chronic nonspecific lung disease, pulmonary fibrosis tissue.

     Contraindications : Giperchuvstvitelnost, allergic reactions to drugs from the ovary cells of Chinese homyachkov, pregnancy, breastfeeding, childhood (up to five years).

     Side Effects : Allergic Reactions (laryngitis, pharyngitis).

     Networking : Compatible with HP (antibiotics, bronhodilatatory, corticosteroids, analgesics).

     Dosing and Administration : Ingalyatsionno; On ampoule (2.5 mg) a day; It could be a 2-vials a day in older patients. Length receive no less than 14 days, the best results (reducing the frequency of exacerbations of infection, improved respiratory function outside) achieved with 6-month course of treatment.

     Special instructions : Do not mix in the drug inhalation of other drugs, because may decrease its activity.

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