DOFAMIN (Dophaminum, Dofaminum). 2 - (3, 4-Dioksifenil) - ethylamine, or oksitiramin.

     C inonimy : Dopamin, Dopmin, Aprical, Cardiosteril, Dopamex, Dopamin, Dophan, Dopmin, Dynatra, Hydroxytyramin, Intropin, Revivan.

     For use as a medicine is something synthetic get through.

     On chemical structure is quite kateholaminom and has several pharmacological properties characteristic of adrenergic substances. He has a special influence on dofamine receptors, which is an endogenous ligand, but in large doses, it also promotes? And? - Adrenoretseptory. Adrenoretseptory impact on the ability of dopamine release Levophed granulyarnyh (presinapticheskih) depot, ie adrenomimeticheskoe have indirect effects.

     Under the influence of something happening to improve peripheral vascular resistance (less severe than under the influence noradrenalina) and increased systolic blood pressure (the result stimulyapii? - Adrenoreceptor) increases heart reduction (by stimulating? - Adrenoreceptor), increased cardiac ejection. The frequency of heart changed relatively little. Need attack oxygen increases, but the increase in coronary blood flow is increased oxygen delivery.

     As a result, specific binding to receptors dofamine kidney showing decreases renal vascular resistance, increases in renal blood flow and filtration. In addition, the rising natriyurez, is also expanding mesenterique receptacles. These acts of renal and vascular mesenterique quite different from the rest (noradrenalina, contests, etc.). In high, but doses (to put people in doses exceeding 15 µ g / kg per minute) start may cause narrowing of kidney diseases.

     Dopamine also ingibiruet aldosterone synthesis.

     The pharmacological effects are showing it intravenously; In giving stomach poorly absorbed. Because it decomposes rapidly, the main way to use a slow drip cefuroxim.

     After the blood-brain barrier penetrating, and not something to put in the vein does not affect the central nervous system (see Tools for treatment parkinsonizma).

     Testimony to the start of a decade of different etiology : kardiogenny trauma, endotoksichesky, aftercare, hypovolaemic shock, and others with less influence on the peripheral vascular resistance increases renal blood flow and blood flow in other internal organs, less hronotropnym effects and other features of release consider these cases illustrated more than Levophed and catecholamines.

     Dopamine is also employed to improve hemodynamics in acute cardiac and vascular insufficiency, developing the various pathologic conditions.

     Enter start intravenous drip; 25 or 200 mg preparation plants in 125 or 400 ml of 5% glucose solution and isotonic sodium chloride solution (quite content in 1 ml respectively 200 or 500 µ g).

     The initial speed of 1 to 5 µ g / kg per minute (2-11 drops 0.05% solution). If necessary, a speed increase of up to 10 to 25 µ g / kg per minute (average of 18 µ g / kg per minute).

     Infusion produce continuous period of 2 to 3 hours to 1 to 4 days. Daily dose is 400 to 800 mg.

     The operation is quick and ends after 5 - 10 min after injection.

     Optimal dose required, in each case, identify under continuous hemodynamic and ECG. Bear in mind that excess optimal dose dopamine can lead to a significant increase in heart, which could exacerbate local and general ischemic and adversely affect the functional status of ishemizirovannogo attack. Large doses can cause quite tachycardia and arrhythmia, kidney vazokonstriktsiyu. Reducing diureza without hypotension points to the need to reduce the dose. In developing the appropriate departments of complications funds (lidocaine, etc.).

     In gipovolemicheskom shock should be combined with the introduction of something plazmozameschayuschih plasma or drugs (or blood).

     Product : 0.5% or 4% solution in ampoules to 5 ml (25 or 200 mg release).

     Storage : List B. In the dark spot.

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