DOBUTAMIN (Dobutaminum) *. (#) (4-[2-parameter Oksifenil) -1 - metilpropil] -3, 4-dioksifeniletilamin (hydrochloride).

     Synonyms: Dobuzhekt, Dobuject, Dobutamine, Dobutrex, Inotrex.

     According to the chemical structure kateholaminom and is the closest to dofaminu (see), which differs from that one hydrogen atom replaced aminogruppy there Paralympic oksifenilmetilpropilny Radikal.

     Dobutamine is a stimulant polling b 1-adrenoretseptorov osteoporosis, and has therefore inotropnoe strong influence on the heart. It acts directly on these receptors and differs from dofamina providing indirect effects (by crowding out noradrenalina of granulyarnyh depot). Dobutamine almost no effect on vascular Adrenergic. He little impact on automatic ventricular has weak hronotropnym action, which if it is applied less (than other rest), the risk of developing aritmy.

     Unlike dofamina Dobutamine is expanding vascular kidney, but the rise in cardiac ejection he can improve cardiac and kidney Diurez increase in patients with heart disease. In connection with inotropnym effect increases coronary blood flow. Peripheral vascular resistance decreased slightly.

     Dobutamine kardiotonicheskoe apply as a means of reducing the need to strengthen briefly infarction: cardiac decompensation in activities related to organic heart disease or surgical intervention at heart. Apply the product only in adults (in the absence of sufficient experience with children).

     Enter Dobutamine intravenously usually at speeds of 2, 5 and 10 µ g / kg per minute.

     The product razvodyat in sterile water for injection, or 5% glucose solution should not be confused solution dobutamina with alkaline solutions). Initially razvodyat 250 mg drug in the 10-20 mL solvent, and then added to the necessary concentration razvodyat 5% glucose solution or 0.9% sodium chloride solution. The speed and length of deal depending on the effect.

     Using the drug could tachycardia, increased blood pressure, Cumulative zheludochkovye arrhythmia, as well as nausea, headache, pain in the heart. These phenomena are reduced with the introduction of speed.

     The product contraindications to idiopaticheskom gipertroficheskom subaortalnom stenosis.

     Method of issuance: in vials with a capacity of 20 ml, containing 250 mg (0.25 g) dobutamina; 5% solution ( "concentrate for injection) in the ampoule and 5 ml (250 mg vials).

     Storage: List B. In sheltered from the world scene.

Materials allowed to copy only with the active hyperlink to the handbook of medicines