DIPIRIDAMOL (Dipyridamolum). 2, 6 - Bis [bis - (b-oksietil) - amino] -4, 8-di-N- piperidino- pirimido (5 4-d) Pyrimidine.

     Synonyms : Kurantil, Persantin, Anginal, Antistenocardin, Apricor, Cardioflux, Coribon, Corosan, Coroxin, Curantyl, Dilcor, Dipiridamole, Dirinol, Novodil, Padicor, Peridamol, Persantin, Stenocardil, Trancocard, Vadinar, Viscor and others.

     The yellow crystalline powder. It is soluble in water.

     Dipiridamol was originally proposed as koronarorasshiryayuschego (antianginalnogo) funds.

     The experimental data, product expands the coronary vessels, the volumetric rate increases coronary blood flow, improves the supply of oxygen attack. Increases tolerance attacks to hypoxia. If the blood circulation in the major coronary vessels, the drug improves blood circulation in kollateralnoy vascular network. It leads to reduced total peripheral resistance, a few drops AD system, improving cerebral blood circulation.

     In the framework of sosudorasshiryayuschego dipiridamola essential to strengthen education adenosine, a partner autoregulyatsii coronary blood flow. Dipiridamol is adenozindezaminazy-competitive inhibitor of the enzyme adenosine off.

     An important feature dipiridamola include its ability to inhibit platelet aggregation and prevent a phlebo receptacles. Apparently, the drug stimulates the biosynthesis prostatsiklina and inhibits the synthesis tromboksanov (see Prostaglandiny).

     As koronarorasshiryayuschae means dipiridamol is currently limited. Used sometimes with chronic ischemic heart disease.

     Is inside (shock for 1 hour before meals) for 0,025 - 0,05 g (1 - 2 pills to 0,025 g) three times a day. In more severe cases of 0,225 grams (225 mg-3 pills to 0,075 grams) a day in three installments. The course of treatment lasts from several weeks to several months.

     Enter dipiridamol intravenously (as suggested in cases of acute strokes) is not recommended. There is evidence that there may uneven redistribution of blood flow in coronary vessels (victimize phenomenon), accompanied by a growing phenomenon strokes with depression in the ECG segment S T.

     Basically antiagregatsionnoe used as a means to prevent postoperative brain, and heart attacks, breaches of cerebral circulation.

     There is an improvement by dipiridamola rock performance and kidney function in patients with chronic glomerulonephritis.

     Dipiridamol affects arahidonovoy acid metabolism, and increase product prostatsiklina in vascular walls.

     On antiagregatsionnoy activity dipiridamol losing tiklopidinu, close to acetylsalicylic acid. However, he moved better than acetylsalicylic acid, does not have ultserogennogo action.

     Is inside as a means of antitromboticheskogo 0,025 g (25 mg) three times a day.

     Dipiridamol usually well. In some cases there are short-term Blush person (salts action), increased heart rate, allergic skin rashes.

     The drug is not suitable for distributed sclerosing atherosclerotic coronary arteries. When parenteral introduction should not be allowed into the solution under the skin (probably irritated tissue). We should not impose intravenously with prekollaptoidnyh state and collapse.

     One can not confuse a syringe dipiridamol with other drugs (possibly falling sludge).

     Method of issuance : pills (pills) at 0,025 and 0,075 grams; 0.5% solution in ampoules of 2 ml (0.01 g).

     Storage : List B.

     Use as a means antiagregatsionnogo has also pentoksifillin (see).

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