DIPRAZIN (Diprazinum). 10-(2-Dimetilaminopropil) - fenotiazina hydrochloride.

     Synonyms : Pipolfen, Allergan, Antiallersin, Atosil, Fargan, Phenergan, Pipolphen, Promazinamide, Promethazine, Promethazine hydrochloride, Promethazini hydrochloridum, Prothazin and others.

     The white crystalline powder. Very easily soluble in water, easily in alcohol; PH 2, 5% aqueous 3, 9, 4, 9. Powder and aqueous solutions of age under the influence of light.

     Promethazine is derived fenotiazina; For texture, and partly and pharmacologically similar to aminazinu. The most important feature of pharmacological diprazina is his strong protivogistaminnaya (N-1 blocker) activity.

     Promethazine well absorbed by ingestion. In different ways of penetrating through the blood-brain barrier

     The drug has expressed influence on the central nervous system; A fairly sedate activity, aggravating drugs, sleeping pills, and analgeziruyuschih mestnoanesteziruyuschih funds, lowers the body temperature, and warns soothes vomiting. It also provides a modest peripheral and central holinoliticheskoe effect. Very expressed adrenoliticheskoe diprazina effect.

     Promethazine applied in the treatment of allergic diseases (Urticaria, whey disease, hay fever, etc.), with vazomotornyh and allergic rhinitis, and allergic disorders with a pronounced component, as allergies complications caused by penicillin, streptomycin and other drugs, as well as zudyaschih Medicine , disease Menera, trochaic, encephalitis and other diseases, central nervous system, leading to increased vascular permeability, with sea and air sickness. In surgical practice Promethazine is used as an essential component of political mixture (see Aminazin) used to potentsirovannogo narcosis and hypothermia, for the prevention and reduction of postoperative complications during the operation and aftercare period. Applied also to enhance actions analgetikov and local anesthetics.

     Assign inside (after eating), intramuscularly and intravenously. Under the skin, not impose, because of its irritating effect.

     Adults inside appoint 0,025 g 2 - 3 times a day, the muscles in 1 - 2 2 ml, 5% solution; Intravenous injection of a mixture of political input to 5 to 10 ml of 0.5% or 2 2 ml, 5% solution.

     Children designate Promethazine smaller doses in accordance with the age. Under the dose inside for children aged 1-2 years is usually 0.0025 grams daily 0.0075, 0.01 g; At the age of 3 to 4 years off 0,005 g, 0,015 g daily; 5 - 6 years single-0.0075 - 0.01 grams daily 0,025 - 0.03 g; 7 to 9 years off 0.01 g, 0.03 g daily; 10 - 14-time 0,015 grams daily 0,045 g.

     To prevent motion (against sea and air sickness) Promethazine appoint one for 1 h to visit adult dose of 0,025 0,05 g, children - - 0,02 0,01 g.

     Higher doses for adults inside : single 0,075 g, 0.5 g daily; Intramuscularly : single 0.05 g (2 2 ml, 5% solution), the daily 0.25 g (10 mL 2, 5% solution).

     Promethazine is usually well. When ingestion can cause moderate anesthesia mucous membranes of the oral cavity; Sometimes dry mouth, nausea. With the introduction intramuscular may be painful infiltrates. When intravenously, sometimes severely lowered blood pressure. A person in violation of the functions of the liver and kidneys Promethazine should be used with caution. As the drugs to the drug must be applied with caution to those in a state of drunkenness. During treatment diprazinom forbidden to drink alcohol.

     There should be appointed Promethazine with itch and other allergic reactions caused by the use of drugs fenotiazinovyh (aminazina etc.), since I was a drug Promethazine this chemical group.

     In connection with the sedative effect can appoint Promethazine during transport drivers and others whose jobs require rapid mental and motor responses.

     Method of issuance : pills to 0,025 g-coated yellow; Bean to 0,025 and 0.05 g; 2, 5% solution in 2 ml ampoules; Pills to 0,005 and 0,01 g-coated white children (Ta bulettae Di r and r zini 0,005 e r t r 0.01 obductae on infantibus) in a package of 10 pieces.

     Storage : List B. Powder in densely ukuporennyh banks dark glass in a dry, the dark places; Tablets and capsules, in the dark place.

     M and P r h e and h is Promethazine has irritating effects, and may cause dermatitis and irritated mucous membranes. With diprazinom must comply with the same precautions as you would for aminazinom.

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