DIPIN (Dipinum). 1, 4 bis-[N, N'di (Ethylene) - fosfamid] - piperazine.

     The white crystalline powder. Mg in the water, easy-to alcohol. Aqueous solutions gidrolizuyutsya easily.

     Dipin, like others, a group etilenimina (tiofosfamid etc.), development proliferiruyuschey injures tissue, including malignant.

     Applied for the treatment of chronic limfoleykozov underway with opuholevidnymi mounting, with the leukocyte count in the blood of more than 75 x 10 9 / L and a rezistentnostyami to radiation therapy. There are performance dipina with laryngeal cancer, vaginal cancer and some other malignant processes.

     Enter intravenously or intramuscularly.

     The drug produces a sterile dried powder or porous white or slightly yellowish sheen in hermetically ukuporennyh bottles of 0.02 g (20 mg). Solutions are ex tempore in 2 or 4 ml isotonic sodium chloride solution (to receive 1% or 0.5% solution).

     In chronic lymphoblastic begins with the introduction of 5 mg (1 ml of 0.5% solution) or 10 mg daily (2 ml of 0.5% solution) in a day. In the future, the interval between injections may be prolonged until 2 to 3 days (depending on the effects and results of Haematology Research).

     With good endurance and where 4 - 5 introductions drug dose 5 to 10 mg did not result in a decrease in leukocyte dose may be increased to 15 mg (3 ml of 0.5% solution). With very rapid reduction in leukocyte drug impose dose of 10 mg to 5, with the increase in the interval between injections to 3 to 5 days. The total dose depends on the clinical effect and influence on krovetvornuyu system; Usually the total number of drug treatment can be brought to 0.2 g (200 mg).

     Drug treatment should be under the careful supervision of Hematology : every 2 to 3 days, determine the cells, and platelets in peripheral blood weekly to common blood test. With a decrease in leukocyte count of 30 x 10 9 / L treatment dipinom stop, given an aftereffect of preparation, continuing until 3 to 4 weeks. If the number of cells would soon be increased again, can resume treatment dipinom to establish therapeutic effect, choosing to 5 mg per injection.

     Treatment dipinom preferably combined with kortikoidnyh drugs and generally strengthening therapy.

     When expressed anaemia appointment dipina combine the blood transfusion (eritrotsitnoy mass).

     If vaginal cancer dipin give dose 30 mg (3 ml of 1% solution) in 3 days or 40 mg (4 ml 1% solution) through 4 days. With slow and a slight decrease in the number of cells and platelets, a process repeated three times, and then gradually reduce the dose to 20 mg 5. With the dramatic reduction in leukocyte and thrombocyte lower dose after the first injection to 20-10 mg and increase the interval between the introduction. With a decrease in leukocyte count to 3, 5 x 10 9 / L, and platelets 100 x 10 9 / L treatment ceased. Treatment usually requires 200-240 mg drug; Appropriate treatment can be repeated after 1, 5, 2 months with blood leukocyte content of not less than 5 x 10 9 / L, platelets is not less than 200 x 10 9 / L.

     Introduction dipina sharp drop in radiation and thrombocytopenia. If necessary, blood transfusions, trombotsitnuyu mass designate blood stimulants, vitamins. Recommended amounts stimulate blood transfusions.

     In some cases, the application appears dipina nausea and decreased appetite.

     The drug is contraindicated in leykopenicheskih and subleykopenicheskih forms lymphoblastic with chronic lymphoblastic disease with a calm (not expressed opuholevidnyh a wider), with heavy liver and kidney diseases, severe anemia and thrombocytopenia expressed.

     Product : to 0.02 g in vial (Dipinum lyophilisatum 0.02 pro injectionibus) in a package of 10 bottles.

     Storage : List A. In the dark place at a temperature no higher than + 10 C.

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