DIOKSIDIN (Dioxydinum). 1, 4-oxide Di-N- 2, 3-bis - (oksimetil) hinoksalina. 3 elenovato- yellow crystalline powder and odourless. Little is soluble in water and alcohol; PH 1% solution of 5, 2, 7, 2.

     Dioksidin like hinoksidinu a broad spectrum antibacterial drug action. Effective with the infection, caused by crude Protea, Bluepus wand wand dysentery bacilli and Klebsiella (Friedlander), salmonella, staphylococcus, streptococcal, anaerobami pathogens (including the cause gas gangrene). There are strains of bacteria resistant to other chemotherapy drugs, including antibiotics.

     Applied to treat chronic inflammatory processes in various sites : introducing plevritov, empiemy pleura, sprang light, peritonitis, tsistitov wounds with a deep cavities : soft tissue abscesses, phlegmons, postoperative wounds and urinary gallons ways, etc., as well as for prevention infectious complications of bladder catheterization.

     Implemented in the form of 1% aqueous solution (1% Solutio Dioxydini pro injectionibus) - greenish-yellow transparent liquid.

     Assign adults only. Before treatment to the portability of drug samples, which are situated in 10 ml of 1% solution. Absent during the 3-6 h side effects (dizziness, vomiting, increased body temperature), are beginning to exchange treatment. Otherwise, the product is not appointed.

     Enter solution in the cavity through the drainage tube, or catheter pumps usually between 10 and 50 mL 1% solution (0.1 - 0.5 g).

     The maximum daily dose of 70 ml of 1% solution (0.7 g). Applied usually one or two times a day (not exceeding the maximum daily dose of 70 ml of 1% solution).

     The length of treatment depends on the severity of disease, treatment effectiveness and transferability. With good endurance, imposed during the three weeks or more. If necessary, repeat the treatment through 1 - 1, 5 months.

     When heavy septic condition drip intravenously injecting 0.5% solution of the drug, which grow in 5% glucose solution and isotonic sodium chloride solution to the concentration of 0.1 - 0.2%. Daily intake of 600 to 900 mg (2 to 3 admission).

     When treating sores wounds, burns, food wounds, skin diseases gnoynichkovyh designate ointment 5%, 1% and 0.5% dioksidina solution.

     Dioksidin should be under close medical supervision.

     Contraindications : individual neperenosimost and that the history function adrenal insufficiency.

     In the experiment, revealed teratogenic and embriotoksicheskoe dioksidina effect, and therefore it is contraindicated in pregnancy.

     The drug is also mutagenic effects.

     In connection with these events dioksidin appointed only when severe forms of infectious diseases or other antimicrobial drugs ineffective. Do not allow uncontrolled use of dioksidina and its dosage forms.

     With insufficient kidney function dioksidina dose should be reduced.

     Entering dioksidina in veins or cavities possible headache, vomiting, increased body temperature, diarrhoeal phenomenon apnoea muscle car. To prevent adverse reactions to the appointment protivogistaminnyh drugs and medicines calcium. When adverse events should be reduced dose appoint antihistamines means, as appropriate, to accept dioksidina.

     Method of issuance : 1% solution in 10 mL ampoules (in the package of 10 vials) for intraoral and local applications; 0.5% solution in capsules of 10 and 20 mL of intravenous, intraoral and local applications; 5% in tubes of ointment of 25 and 50 g.

     Storage : List B. In the dark spot.

Materials allowed to copy only with the active hyperlink to the handbook of medicines