DIMEDROL (Dimedrolum). b-Dimetilaminoetilovogo benzhydrol ester hydrochloride.

     C inonimy : Alledryl, Allergan, Allergival, Amidryl, Benadryl, Benzhydraminum, Diabenyl, Dimedryl, Dimidril, Diphenhydramine, Diphenhydramini hydrochloridum, Diphenhydramine hydrochloride, Restamin etc.

     White powder melkokristallichesky bitter taste. Language is showing. Gigroskopichen. The easily soluble in water, very easily in alcohol. Aqueous solutions (pH 1% solution of 5, 0, 6, 5), with 100 sterile 'C for 30 min.

     Diphenhydramine is one of the main representatives of the group protivogistaminnyh to block N-1 receptors. He has expressed very protivogistaminnoy activity. In addition, he has mestnoanesteziruyuschee action relaxes smooth muscles as a direct result of blocking receptors in a moderate way holinoretseptory vegetative nervous knots.

     Diphenhydramine well absorbed by ingestion. Penetrates through the blood-brain barrier.

     An important feature is its dimedrol sedative action which has some similarities with the operation neyrolepticheskih substances; In appropriate doses, it has the effect of sleeping pills. He is also a moderate antiemetics funds. In dimedrol effects on the nervous system is essential, along with the impact on gistaminovye receptors (possibly N-3 receptor brain), its central holinoliticheskaya activity.

     Diphenhydramine is used primarily for the treatment of urticaria, hay fever, whey disease, hemorrhagic vaskulita (kapillyarotoksikoza) vazomotornogo fever, swelling angionevroticheskogo, zudyaschih dermatosis, iridotsiklita severe, allergic conjunctivitis and other allergic diseases, allergic complications from receiving various medicines, including antibiotics .

     Like other protivogistaminnye preparations dimedrol used in the treatment of radiation sickness.

     In bronchial asthma dimedrol relatively little activity, but it can assign to the disease in combination with teofillinom, ephedrine and other drugs.

     Sometimes dimedrol used in gastric ulcers and gastritis giperatsidnom, but much more active in this disease are blockers N-2 receptors (see Tsimetidin, Ranitidin).

     Diphenhydramine (the same as other blockers N-1 receptors) can be used to reduce adverse events in blood transfusions and blood fluids, the use of enzyme and other drugs.

     Applied also dimedrol with trochaic, sea and air sickness, vomiting during pregnancy, Menera syndrome. The therapeutic effects of the drug in these diseases may find an explanation in his sedate and central holinoliticheskom action. On protivorvotnoy activity better than dimedrol it is integrated with salt hlorteofillinom (Dimenhydrinate).

     Applied also dimedrol as a means of calming and sleeping pills alone and in combination with other drugs. Assign the inside of one pill (0.03 or 0.05 grams) before bedtime.

     In practice anaesthetics used as an integral part of political mixture (see Aminazin).

     Assign dimedrol inside, intramuscularly, in the vein, the local (nakozhno, in the form of eye drops, the mucous membrane of the nose); Also introduced rectally.

     Under the skin, not to impose because of irritants.

     Inside designate pill for adults 0.03 - 0.05 g 1 to 3 times a day. The course of treatment 10 to 15 days.

     In the muscle to impose 0,01 - 0,05 g in a 1% solution, in non-drip method 0,02 - 0,05 g dimedrol 75-100 ml isotonic sodium chloride solution.

     Children dimedrol designate smaller doses : up to 1 year, 0,005 to 0,002 g, 2 to 5 years - 0,005 - 0,015 grams, from 6 to 12 years on the 0,015 - 0.03 g at a reception.

     Candles with dimedrol give rectum 1 to 2 times a day after sweeping enema or spontaneous bowel cleansing. Children under the age of 3 years are designated candles containing 0,005 grams of dimedrol; From 3 to 4 years to 0.01 g; From 5 to 7 years to 0,015 g, 8-14-0.02 g.

     Higher doses for adults inside : single 0.1 g, 0.25 g daily; Intramuscularly : single 0.05 g (1 ml of 5% solution), the daily 0.15 g (15 mL 1% solution).

     For the backfilling of konyunktivalny bag using 0,2 - 0,5% solution (best of 2% solution of boric acid) for 1 to 2 drops of 2 - 3 - 5 times per day.

     Sometimes dimedrol applied in the form of creams or ointments (3-10%), built in the pharmacy for lubricating skin in zudyaschih Medicine. It should be borne in mind that dimedrol absorbed through the skin and lubricating large surface can cause intoxication : dry mouth, difficulty in breathing, stir, sputannost consciousness'.

     In allergic vazomotornyh, acute rhinitis, rinosinusopatiyah designate dimedrol nose in the form of sticks (with wand dimedrol, you illi cum Dimedrolo) containing 0.05 g dimedrol to polietilenoksidnoy basis. You can also use cooked ex tempore masi and drops.

     The reception inside dimedrol, on his mestnoanesteziruyuschim action may be short-term "denial" mucous membranes of the oral cavity; In rare cases, possible dizziness, headache, dry mouth, nausea. Adverse events are self after the drug or reducing the dose.

     Due to the influence of the drug on central nervous system disturbances may occur and the overall weakness.

     Because of the sedative and pain of dimedrol not appoint reception during transport drivers and others whose jobs require rapid mental and motor responses.

     Method of issuance : powder; Pills to 0.02; 0.03 and 0.05 g; Candles with dimedrol to 0,005; 0,001; 0.015 and 0.02 g; Wand of 0.05 g; 1% in injectable solution and dye tube. Candles with dimedrol intended for use in pediatric practice.

     Storage : List B. The well ukuporennoy packaging keeps out of light and moisture. Tablets and capsules, in the dark places; Candles in a dry, cool, the dark spot.

     Rp. : Tab. Dimedroli 0.05 N. 10

     D.S. He is 1 / 2 to 2 1 pill twice a day (with allergic diseases; On one pill at night (as sleeping pills)

     Rp. : Sol. Dimedroli 1% 1 ml

     D.t.d. N. in ampull 6.

     S. On January 1 ml of muscle-2 pa said the day

     Rp. : Dimedroli 0.02

     Borici Acidi 0.2

     Aq. destill. 10 ml

     M.D.S. Eye drops; Allah will drop 1 - 2 2 -3 times a day

     Rp. : Dimedroli 0.01

     Ephedrini hydrochloridi O, 1

     Ol. Persicorum 10 ml

     Ol. Menthae gtt. III

     M.D.S. Ka man in the nose; 2 to 3 drops of 3 to 4 pa for a day

     Rp. : Bacilli cum Dimedrolo 0.05 N. 10

     D.S. For one stick in each half of the nose

     Rp. : Supp. cum Dimedrolo 0.02 N. 10

     D.S. In one county in c rectum (children 10 years old)

     Rp. : Dimedroli

     Anesthesini

     Mentholi aa 1 0

     Sol. Borici Acidi 2%

     Spir. Vini 96% aa 100 ml

     M.D.S. For lubricating skin itch when

Materials allowed to copy only with the active hyperlink to the handbook of medicines