DIGOKSIN (Digoxinum).

     Glycoside contained in the leaves lapidary woolly (Digitalis lanata Ehrh.)

     C inonimy : Cedoxin, Cordioxyl, Digolan, Digoxin, Dilanacin, Dixina,

     Lanacordin, Lanacrist, Lanicor, Lanoral, Lanoxin, Natidigoxine, Oxydigitoxin and others.

     The white crystalline powder. Almost nerastvorim in water, very little of alcohol.

     According to the circulation of close to other cardiac glycosides.

     For high kardiotonicheskay activity : 1 g product contains 4000 (3277 - 4347) KED or 1950-2600 GED. Has strong Systolic cal act on the very slow heart rhythm. Has also expressed about diuretichesky effect. Compared with Digui toxin derived from the body faster and less able to cumulation in the body. Digoxin less than digitoksin and other glycosides Naper styanki, has been associated with serum proteins and is approaching this in regard to the strofantinu.

     Digoxin well absorbed by ingestion. Kardiotonichesky cash effect is usually 1 to 2 h and reaches over 8 hours

     With the admission of a 20-by 30 minutes and reached a maximum after 3 hours

     Applied with chronic circulatory failure I-II A and

     II B degree, as well as a few tahiaritmicheskoy predserdy, paroxysmal mertsatelnoy adults, supraventrikulyarnoy paroxysmal tachycardia.

     Assign digoxin, inside or intravenously (struyno drip).

     Rapid intake and a strong opportunity to receive the necessary therapeutic effect in the employment drug inside. By intra-governmental injections administered in heavy circulatory violations.

     Inside digoxin designate usually on the first day of 0.25 mg (one tablet) 4 - 5 times with equal intervals (1, 1, 25 mg / day), in the coming days to provide 0.25 mg 3 times in one day. Dose make, given the figures

     ECG, respiration, diureza. Depending on the effect of repeating previous dose or gradually. A patient must be under close medical supervision.

     After achieving the necessary therapeutic effect over the treatment dose of digoxin supporters : 0.5 - 0.25-0,125 mg (2 - 1 1 / 2 tablets) a day. Usually within 1 - 1 5 weeks (sometimes before) can find the correct dose for each patient support glycoside for a long application.

     Higher daily doses of digoxin for adults 0.0015 mg (1, 5 mg).

     Doses for children are picked strictly individual; Tentatively for "saturation" drug use rate of 0.05 - 0.08 mg / kg. This includes many plots can be entered for the 1 - 2 days (rapid method of digitizing), or 3 - 5 days, or within 6 to 7 days (slow "saturation").

     For injections digoxin designate adult dose of 0.25 - 0.5 mg (1 2 ml 0.025% solution); Enter slowly, in the vein of 10 ml of 5%, 20% or 40% solution of glucose or isotonic sodium chloride solution in the first days of 1 to 2 times a day in the future-1 time per day (during the May 4 days) and then transferred to a reception inside the drug in doses supporters. For drip infusion grow 1 to 2 ml of 0.025% solution of 100 ml of 5% glucose solution and isotonic sodium chloride solution and give veins at speeds 20 to 40 drops per minute.

     In overdose possible slowdown conductivity heart bigeminiya, nausea, vomiting, loss of appetite and other side effects, watching the play with an overdose of other cardiac glycosides.

     Application of digoxin requires care in acute coronary not sufficient, especially in acute myocardial infarct with ventricular arrythmia, and with the active myocarditis and expressed aetiology.

     Digoxin is not suitable for closure hearts and intoxication earlier ously drugs lapidary.

     For patients with renal insufficiency dose reduced (approximately 2 times).

     Introduction strofantina permitted to no earlier than 24 hours after digoxin.

     Method of production : tablets of 0.25 mg (0.00025 grams), and 0.1 mg (0.0001 grams) for children; 0.025% solution (0.25 mg) in 1 ml ampoules.

     R p. : Ta b. Digoxini 0.00025 N.50

     D.S. At one pill 1 to 3 times a day, adults

     R p. : S for l. Digoxini 0.025% 1 ml

     D.t.d. N.5 in ampull.

     S. At 1 ml in 10 ml of intravenous 5% glucose solution

     Enter slowly.

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