DIFLUNISAL (Diflunisal). 2, 4-Diftor-4- oksi-3- bifenilkarbonovaya acid.

     Synonyms : Dolobid, Adomal, Algobid, Cididol, Diflonid, Diflunil, Dolisal, Dolobid, Flovacil, Flunidor, Fluodonil, Noalodol and others.

     Nesteroidnoe analgesic and antiinflammatory. Has prolonged action. After a single admission into effect occurs during the first hour, reaching a peak after 2 to 3 h, 12 h and still more.

     Like other steroidal antiinflammatory drugs, diflunizal ingibiruet prostaglandines biosynthesis, but the mechanism of drug action is not fully understood.

     Applied diflunizal (dolobid) for more edema, especially in inflammatory processes : osteoarthritis, rheumatoid arthritis and others. Also nominated in algodismenoree.

     Is the interior in the form of tablets; Pills not razlamyvayut not razzhevyvayut; ?high water.

     The recommended dose for adults : elementary (shock), 1 g; Subsequent (supporting), 0.5 g at intervals from 8 to 12 h. We should not take more than 1, 5 g per day.

     Possible side effects and precautions are basically the same as the application of other non-steroid anti-drugs (diarrhoeal phenomenon, allergic skin reactions, passing <<fog>> view, etc.).

     Diflunizal (dolobid) is not suitable for stomach ulcers and gastrointestinal cancer (particularly in the treatment of gastrointestinal krovotecheniyah), high sensitivity musk and other steroidal antiinflammatory drugs, pregnancy and breastfeeding. It should appoint a drug to children (because of the lack of sufficient experience). Caution should be observed in the breach as kidney and eye disease (need for eye control).

     There should be appointed diflunizal (dolobid) with indometacin (risk of gastrointestinal bleeding), acetylsalicylic acid (diflunizala lower concentrations in plasma). Diluted aggravating anti kumarinovyh.

     Product : tablets for 0.25 and 0.5 g.

     Storage : List B. In dry, the dark spot.

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