DIBUNOL (Dibunolum) (see also Tokoferola acetate). 2, 6-Di-tert butil-4- metilfenol.

     Synonyms : Butiloksitoluol, Ional.

     White or white to slightly yellowish sheen crystalline powder. Almost nerastvorim water, easily soluble in alcohol.

     BHT, a key group of antioxidants, ie compounds that are free-response inhibitors.

     Some research shows that the various pathological conditions resulting from violations of free-reactions in lipid membranes, resulting in the intensification of peroxide oxidation of lipids. In recent years found that the organism are endogenous compounds that have slowed the peroxide oxidation of lipids (POL). One of these compounds enzyme superoxidedismutase - acceptor is oxygen free radicals, inhibiting the peroxide oxidation of lipids and proteins. I think therefore that superoxidedismutase can be applied to the treatment and prevention of various diseases.

     However, there are exogenous substances (drugs), is actively inhibiting POL (antioxidants), corrective kislorodzavisimye pathological condition. At the same time, they are antigipoksantami.

     One of the main antioxidants is tokoferola acetate (see).

     BHT, has expressed antiradikalnoy (antioxidant) activity was first proposed for local application in the form of 10% linimenta in treating cancer and papillomatoza bladder. Currently, it is also employed in anesthetic, superficial burns, otmorozheniyah I-II degree, the long-term healing ray and trophic ulcers, low granuliruyuschih wounds.

     In connection with antioxidant properties and antihypoxic dibunola studying its effectiveness in various diseases involving activated peroxide oxidation of lipids.

     Applied BHT as vnutripuzyrnyh instillyatsy (10% Liniment) with bladder disease and External (5% Liniment) with burns, otmorozheniyah, anthrax and others.

     For vnutripuzyrnyh instillyatsy directly to the use of 10 g 10% linimenta dibunola to throw 24-30 ml - 1, 0.25% solution of novocaine to vnutripuzyrnogo consistency suitable for the introduction and then obtained solution (35 ml - 40) enter syringe on the catheter in pre oporozhnenny uric bubble. Before instillyatsii recommended that washed away antiseptic solution. A patient must retain BHT in the urinary bladder to regular urine, preferably 2 to 3 hours In cases of severe reaction to a catheter, in the absence of mechanical narrowings urethra acceptable introduction dibunola through the urethra under pressure (to Zhan).

     Instillyatsii drug produced daily. For antiinflammatory effect is required instillyatsy 10 - 15, and sometimes less, and antitumor effect of not less than 25. If improvements in the specified time, it does not, cancel treatment; If found to reduce the size of the defeat, the treatment can be continued for 30 to 40 days. If necessary instillyatsy courses can be repeated depending on the clinical need.

     If burns cause 5% Liniment dibunola thin layer of marlevuyu wounds or bandages, which cover the wounds. Changing bandages to every day or two. The course of treatment 7 to 10 days.

     Can cause Liniment dibunola again the same day.

     In otmorozheniyah, trophic ulcers also apply 5% dibunola Liniment, which cause to the affected areas. If necessary, apply Liniment dibunola with antibacterial and other drugs.

     In DERMA practising as Liniment dibunola treatment method fonoforeza.

     Entering dibunola in the bladder may develop complications related to multiple catheterization (gonococcal urethritis, prostatitis, orhiepididimity). In that case, instillyatsy refused.

     When the outer application dibunola may itch and redness of skin around the cancer. In these cases, medication overturned. With massive burns strupah of 5% linimenta dibunola leads to increased exclusion Slough and necrotic tissue, which may be accompanied by events wet necrosis, kupiruyuschimisya in alternation with casts dibunola furatsilinovymi drying wet bandages.

     Application of 10% linimenta dibunola contraindicated in patients with cancer of the bladder tumors with high germination in paravezikalnuyu fibre, and there metastases (stage T4), with a massive hematuria, azotemii, events acute pyelonephritis, a vesico mochetochnikovogo physically. A ostrozhnost location with tumours in the bladder neck at the risk of tumors with multiple injuries kateterizatsiyah.

     Product : 5 Liniment, and 10% (5% Linimentum Dibunoli e t 10%) mass white with yellow or greenish white in color (10%) or bank (5%).

     Storage : Keep in a cool place protected from the light. Banks should be closed.

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