DIAFENILSULFON (Diaphenylsulfonum). 4 4'- Diaminodifenilsulfon.

     Synonyms : Avlosulfon, Dapsone, Dapsonum, DDS, Diphenason, Dumitone, Eporal, Novophone, Sulfonmere and others.

     White or kremovato- white crystalline powder. Almost nerastvorim in water, soluble in alcohol difficult.

     Has antibacterial action against leprosy and tuberculosis mycobacteria.

     He is one of the main products for the treatment of leprosy.

     Assign into cycles of 4 - 5 weeks with a one-day break every six days. During the first cycle in two weeks to take 0.05 g (50 mg), 2 times a day, in the next three weeks-at 0.1 g, 2 times a day. Then two-week break, followed by a second round of the same pattern. The course of treatment consists of four cycles. After the fourth cycle, making a break at 1 - 1, 5 months. Treatment for long.

     Diafenilsulfon also proposed to treat patients gerpetiformnym Dyuringa dermatitis. Assign inside of 0.05-0.1 g 2 times a day cycles of 5 - 6 days with a break on one day, only 3 to 5 cycles, and more. Once the clinical manifestations of disease, drugs are in support doses : 0.05 g (50 mg) a day or 1 to 2 times a week.

     In applying diafenilsulfona possible side effects : general weakness, diminished appetite, diarrhoeal phenomenon, dizziness, headache, palpitation, pain in the heart; In some cases appear cyanosis, symptoms of toxic hepatitis, anemia.

     In developing adverse effect reduce the dose or temporarily stop receiving the drug. When resistant anaemia, a violation of liver and kidney diafenilsulfon overturned.

     Contraindications : liver disease, kidney disease. Before and during treatment should be systematically testing of blood and urine, explore the functional state of the liver.

     Diafenilsulfon (and solyusulfon) can be taken simultaneously with amidopirinom and barbiturates.

     To prevent and reduce the side effects are encouraged to nominate vitamins, iron preparations.

     Product : powder; And 0,025 tablets of 0.05 g.

     Storage : List B. In dry, the dark spot.

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