Deksfenfluramin (dexfenfluramine)


DEKSFENFLURAMIN (Dexfenfluramine).
     (+) N-Ethyl? m-methyl - (trifluoromethyl) fenetilamin.
     Synonym : Izolipan, Izolipan.
     Available as hydrochloride.
     The structure is similar to simpatomimeticheskimi amines (including fenaminom), but has expressed little central catalytic activity, however, has a strong anoreksigennoe effect.
     Activates serotoninergicheskuyu transfer ventromedialnyh hypothalamic nuclei ( "saturation point").
     Quickly and completely absorbed in the digestive tract, bioavailability of about 70%, S-max 4 h, T? 20-h; biotransformation are in the liver, kidneys out.
     Applied mostly with alimentary obesity, and other conditions requiring reduced body weight.
     Assign to 0,015 g (1 capsule) two times a day (morning and evening) during meals with malokaloriynoy diet. The course of treatment is continuing normally three months. Body mass may decrease over time at 7-10 kg (individual variation). Treatment should be carried out under medical supervision ...
     Possible side effects and contraindications are basically the same as the other drugs in this group (see Fepranon).
     Product : Capsule to 0,015 g (15 mg).
     Storage : A. Otpuskaetsya list only on medical prescription.

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