DEZOKSIKORTIKOSTERONA acetate (Desoxycorticosteroni acetas).

     Pregnen-4- ol-21- glows - 3, 20 acetate.

     Synonyms : DOKSA, Arcort, Desoxycorticosteronum aceticum, Cortarmur, Cortate, Cortenil, Cortexon, Cortinaq, Cortiron, Decorten, Decorton, Decosterone, Decostrate, Descorterone, Descortone, Desoxycortoni acetas, Desoxycortone acetate, DOCA, Dohycamon, Dorcostrin, Percorten, Steraq, Syncortyl et al.

     White or cream shade with weak crystalline powder and odourless. Almost nerastvorim in water, soluble in alcohol and oils.

     The preparation of synthetic get through. Synthetic drug-dezoksikortikosterona acetate (DOKSA), the properties of natural adrenal cortex hormones.

     Dezoksikortinosteron is mineralokortikosteroidom. It was late in the body of sodium ions and potassium increased allocation, resulting in higher hydrophily tissue; While plasma volume increases, rising AD. Dezoksikortikosteron increases tone muscles and improves efficiency.

     Key testimony to the use of a disease DOKSA Edison and the temporary demotion adrenal cortex function (gipokortitsizm). The drug is also used in infants, fatigue, adinamii, overall muscle weakness, gipohloremii and some other diseases.

     Assign intramuscularly in oil solutions. When illness Edison imposed depending on the severity of the illness of 0,005 grams (5 mg) three times a week to 0.01 g (10 mg) daily to reduce the appearance of symptoms, followed by 5 mg 1 to 2 times a week.

     When illness Edison to simultaneously introduce Glucocorticosteroids. Assign the same time, sodium chloride (4 to 10 grams a day in oblatkah or aqueous solution of 10 g sodium chloride with 5 g of sodium citrate and fruit juice).

     In acute lack of adrenal cortex and addisonicheskom Stroke impose a 5-to 10 mg four times a day.

     In addisonizme appointed to 5 mg a day of preparation (15 - 20 injections for treatment), with hypotonic conditions on the grounds of low-adrenal cortex function to 5 mg a day or two days (total 12 - 15 injection).

     Higher doses of adult intramuscularly : single 0.01 g (2 ml of 0.5% solution), the daily 0,025 grams (5 ml 0.5% solution).

     Dezoksikortikosterona acetate can be used in gipokortitsizme in pill form under the language (of the cheek) : appoint 1 / 2 - 1 pill (2, 5, 5, 0 mg) one every day or every other day. Pill kept until resorption, not liquid and not proglatyvaya.

     Drug treatment should be under the close supervision of a doctor. In overdose can develop swelling (due to the delay of sodium and water), increase blood pressure.

     Contraindications with hypertension, heart failure with the swells, atherosclerosis, strokes, nephrite, principally, liver cirrhosis.

     Method of production : 0.5% solution in oil in capsules and 1 ml (0.005 g 1 ampoule); Tablets of 0,005 grams (5 mg) sublingual application.

     Storage : List B. In the dark spot.

     Rp. : Sol. Desoxycorticosteroni aceta tis oleosae 0.5%

     D.t.d. N. in ampull 6.

     S. At 1 ml a day intramuscularly

     R p. : Tab. Tatis Desoxycorticosteroni ace 0,005 N. 50

     D.S. On January 1 pill once a day by language

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