DEFEROKSAMIN (Deferoxaminum) *.

     N-[5 - (3-[(5-aminopentil) oksikarbamoil]) - propionamido pentil] (-3-[5 - (N oksiatsetamido) pentil]) - karbamoil propiongidroksamovaya acid.

     Available in a metansulfonata.

     Synonyms : Desferal, Desferal, Deferoxaminum methansulfonat, Desferan, Desferex, Desferin, Desferrioxamin, DFOM.

     The drug forms an integrated connection to the iron. With the body removes iron from the iron-protein (Mardones and gemosiderina), but not from the hemoglobin and iron enzymes. It does not affect the provision of other metals and trace elements.

     Applied in the primary and secondary hemochromatosis, gemosideroze in acute poisoning and iron.

     The average initial dose of 1 g / day (1 - 2 injection); Supporting dose of 0.5 grams per day.

     Enter usually intramuscularly. Implements 10% solution, which the contents of 1 mg (0.5 g) dissolved in 5 ml of sterile water for injection. Intravenous drip impose only a maximum of 15 mg / kg per hour; The maximum dose of 80 mg / kg.

     In acute poisoning iron appointed interior and parenteral. To associate iron, yet vsosavshegosya from the gastrointestinal tract, are inside 5 - 10 g product, that is the content of 10 to 20 vials (dissolving in water). To remove the iron entering vsosavshegosya intramuscularly for 1 - 2 - 3 g every 12 hours In severe cases, introducing non-drip in one city

     In applying the drug may cause, in some cases, urticaria and exanthema. Fast intravenous can bring to the collapse. With long-term use drugs needed before and during treatment study of the eye. (In the experiment on animals, as long primenenni large doses watched clouded aphykia.)

     Before and during treatment should be explored for iron in the urine.

     The drug is contraindicated in pregnancy.

     Product : in ampulyah containing 0.5 g (500 mg) dry preparation.

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