DALARGIN (Dalarginum).

     Tirozil-2- alanil- glitsil- fenilalanil- leytsil- arginine.

     Peptide compound consisting of six amino acid residues (hexapeptide). Available in a diacetate (X = 2 SNzS OO N). The white amorphous powder, readily soluble in water and alcohol.

     Discovery enkefalinov and nervous (see Analgeziruyuschie funds) and the establishment of the chemical structure led to a growing work on the synthesis of analogues and derivatives. There were a large number of new peptide compounds with different types of neurotropic (analgeziruyuschey, sleeping pills, antidepressant, etc.) activity and other pharmacological properties (see also Timogen). For a variety of reasons (lack of stability; Poor oral application, etc.) until late in the practice of medicine as drugs were a small number of compounds.

     One of the compounds in this group, which has practical application, is a domestic product dalargin.

     Of the pharmacological properties dalargina most notably by its antisekretornaya activity, the ability to accelerate the healing of gastric ulcers and duodenal ulcers, as well as anti-hypertensive effect.

     The drug is recommended for use as a healing agent with worsening stomach ulcer and duodenal ulcer. To this end dalargin designate intravenously or intramuscularly. Under the dose of 0,001 grams (1 mg). Intramuscularly give 1 ml, and intravenous 5--10 ml isotonic sodium chloride solution. Intramuscular injections do two times, and intravenous 1 every day. If necessary, a single dose increased to 0,002 grams (2 mg), daily (intramuscularly) to 5 mg. The course of treatment still 3 to 4 weeks. The total dose of drug to the treatment of 30-50 mg.

     To apply injection dalargin freeze (Dalarginum lyophilisatum 0,001 p on injectionibus r), produced as a powder or porous in ampoules of 0,001 grams (1 mg).

     Solutions for injection prepared immediately before use.

     When expressed pain symptom may simultaneous appointment antatsidnyh funds.

     There are indications of the effectiveness of adjuvant therapy dalargina obliteriruyuschih diseases lower limbs.

     There were also positive dalargina (intravenous slow introduction of 1 mg in 10 ml isotonic sodium chloride solution) at the mental function of alcoholics.

     Injections dalargina usually well transferred; Perhaps lowering blood pressure.

     The drug should not be used in pregnancy and expressed hypotension.

     Product : dried powder or porous mass in ampoules for 0,001 g (1 mg) in a package of five vials.

     Storage : List B. In the dark place at a temperature of not more than + 20 'C.

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