TSITIZIN (Cytisinum).

     Tsitizin alkaloidom is contained in the seeds of plants too (Cytisus laburnum L.) and termopsisa lantsetolistnogo (Thermopsis lanceolata, R. Br.) , Both from the family of legumes (Leguminosae).

     Refers to the substance <<ganglionarnogo>> action in connection with the agitation effect on respiration as breathing analeptik. For this purpose, the form of finished 0.15% aqueous solution called <<Tsititon>> (Cytitonum).

     In recent years tsitizinom were also used as a vehicle for trying smoking (see tablets <<Lobesil>>).

     Tsititon-transparent colorless liquid; PH 7, 0, 7, 5. Sterilize at + 100 C for 30 min.

     Tsitizin incident has ganglii impact on the vegetation of the nervous system and its related education: hromaffinnuyu tissue ? and karotidnye klubochki.

     An action for tsitizina (as lobelina) is the initiation of breath associated with cosmetic stimulation respiratory center stronger impulses coming from karotidnyh klubochkov. The simultaneous excitation sympathetic ? knots and raises blood pressure.

     Effects tsititona (tsitizina solution) for breath is short <<tolchkoobrazny>>, but in some cases, especially when good stops breathing, tsititona use can lead to permanent recovery breathing and blood circulation.

     Earlier tsititon widely used in poison (morphine, barbiturates, carbon oxide, etc.). In response to the emergence of specific opiate antagonists (naloxone, etc.) and barbiturates (Bemegride) and short steps, and tsititon lobelin currently have limited use. Nevertheless, with good stops breathing (operations, trauma, etc.) tsititon can be used as breathing analeptik; In connection with pressornym effect (that distinguishes it from lobelina) tsititon may apply under shock and kollaptoidnyh state, with the oppression of breath and the blood of patients with infectious diseases and others.

     Enter tsititon in veins or intramuscularly: adult for the 0.5-1 ml; For children up to 12 months-0.1 - 0.15 ml; 2 - 5 years - 0.2 - 0.3 ml, 6-12 0 3 - 0.5 ml. The most effective intravenous. Where indicated tsititona injections can be repeated after 15 - 30 minutes.

     Tsititon earlier was also used to determine the speed of blood flow. The method is a time that elapses since the introduction of flat veins tsititona before the first deep breath. Defining more clearly than in a lobelina as arousal disorder expressed otchetlivee and changing breathing easily register. Usually imposed for the purpose 0.7 to 1 ml tsititona (0,015 ml per 1 kg of body mass sick).

     Higher doses of adult intravenously and intramuscularly off 1 mL, 3 mL daily.

     Tsititon contraindications (due to its ability to raise blood pressure) when expressed atherosclerosis and hypertension, bleeding from large vessels, swelling light.

     Form release: in 1 ml ampoule.

     Storage: ampoule with tsititonom B-list; Powder tsitizina-list A.

     Tsitizin (0.0015 g = 1, 5 mg) is a member of the tablets <<Tabeks>> (Tabex, Bulgaria), used to facilitate smoking from smoking. Assign to one tablet to pick first five times a day with a further dose reduction to 1 - 2 pills a day. For persons taking these pills, and smoking develops unpleasant feelings. The course of treatment is continuing 20-25 days.

     The mechanism is similar to the mechanism of drug action and lobelina anabazina.

     Application tablets <<Tabeks>> must be done on purpose and under the supervision of a doctor. In overdose possible nausea, vomiting, increased inhibition, increasing heart, which required the closure of receipt of the drug.

     Also produced films with tsitizinom (Membranulae cum Cytisino). Polymeric oval plate with blunt edges, white or yellowish tinge (9 H, 4 5 X 0.5 mm), contain at 0.0015 g tsitizina. Film thickness on mucosal lining or sheath zaschechnoy field day in the first 3 to 5 days at 4 to 8 times.

     If the effect of treatment continues as follows: from 5 th to 8 th day on one film 3 times a day, from 9 th to the 12 th day of January film 2 times a day, with the 13rd of 15 day 1 1 film every day. On the first day of treatment should stop smoking or drastically reduce the frequency of smoking.

     In the early days of film with tsitizinom possible unpleasant taste sensations, nausea, mild headache, dizziness, low blood davlennya increase. In these cases should stop receiving the drug.

     The use of films to counter tsitizinom with bleeding expressed hypertension, are coming stages of atherosclerosis.

     Form of: 10 pieces in the package or on the contour 50 pieces in a glass tube.

     Storage: List B. In sheltered from the world scene.

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