TSISTAMINA DIGIDROHLORID (Cystamini dihydrochloridum).

     BIS (b-aminoethyl) - digidrohlorid orifice.

     Synonyms: Cystaminum dihydrochloricum, Cystinamin.

     The white crystalline powder or yellowish color with a specific smell (merkaptana). Easy soluble in water solutions to the education background, little soluble in alcohol.

     Tsistamin aminotiolov belonged to the group. The first representative of the group was merkamin (synonyms: Vesar tan, Xu steamine, Me r t and monum ATS), a b-merkaptoetilaminom (HS- CH 2 CH 2--NH 2). Tsistamina molecule can be seen as double molecule merkamina where sulfgidrilnye group (N-S) replaced disulfidnoy connection (-S-S-).

     Aminotioly radiozaschitnoe have preventive effects in acute radiation defeat by increasing the body's resistance to the action of ionizing radiation.

     Effects aminotiolov based on their ability to reduce the number of radicals, and brought ionized molecules formed in the tissues of irradiation, as well as the ability of these compounds interact with certain enzymes and give them resistance against the radiant energy. There are other theories of radio aminotiolov (hypothesis "biochemical shock" Baca and others).

     Äåéñòâèå àìèíîòèîëîâ ïðîÿâëÿåòñÿ áîëåå îò÷åòëèâî ïðè ââåäåíèè çà êîðîòêèé ñðîê (10 - 30 ìèí) äî îáëó÷åíèÿ. The protective effect of a single still about 5 hours

     Tsistamin (in the same way as other aminotioly) used for the prevention and reduction of radiation sickness (general malaise, nausea, vomiting, etc.) arising from the application of large doses of radiation to radio and radiotherapy.

     Assign inwards in the form of tablets for 1 h before irradiation. The dose depends on the nature of the disease, blood condition of the patient, dose of radiation.

     Daily doses ranging from 0.2 to 0.8 g.

     The product is used during the entire course of radiation therapy. At the same time, patients should receive obscheukreplyayuschuyu therapy.

     Application tsistamina already in advanced radiation sickness (with considerable radiation) treatment did not work. The development of radiation medicine not warned. While significantly reducing the number of white blood between exposure and the need to continue treatment can be applied in conjunction with tsistamina LEUKOPOEZIS stimulants; If necessary, designate gemotransfuzin.

     After receiving tsistamina in some cases have burning sensations in the oesophagus, nausea and sometimes pain in the stomach; This phenomenon is usually not an obstacle to continue receiving the drug. Please note that the product has a hypotensive effect; In hypertensive disease may be a significant reduction in AD.

     The relative contraindications to the use tsistamina dihydrochloride are acute gastrointestinal tract diseases, the acute lack of the cardiovascular system, a violation of the functions of the liver.

     Form release: pills for 0.2 and 0.4 g.

     Storage: List B. In a dry, sheltered from the world scene.

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