TSIKLOSERIN (Cycloserinum).

     Cycloserine-antibiotic formed in the life of Streptomyces orchidaceus or other microorganisms; Also receiving synthetic means.

     According to the chemical structure is D-4- amino-3- izoksazolidinon.

     C inonimy: Ciclocarine, Ciclovalidin, Closin, Ciclocarine, Cyclomycin, Cycloserine, Farmiserina, Novoserin, Orientomycin, Oxamycin, Serociclina, Seromycin, Tebemicin, Tibicin, Tisomycin and others.

     The white crystalline powder, slightly bitter taste. Easy soluble in water.

     The product with broad antibacterial action: oppressing gram and gram bacteria. The most valuable feature is its ability to delay the growth of M. tuberculosis. For less activity streptomycin, and tubazidu ftivazidu, but operates in Mycobacterium tuberculosis that are resistant to these drugs and PASK.

     Cycloserine rapidly absorbed from the gastrointestinal tract, into the spinal fluid; Therapeutic concentrations detected in the blood through the 4 - 8 hours after his admission.

     Cycloserine as <<Reserve>> anti-TB drug, ie appointed chronic forms of tuberculosis patients who have previously applied basic medicines to stop the effect. Cycloserine can also be combined with the drugs to prevent the development of resistance testing. It is also possible to use tsikloserina combination with other drugs II series etionamidom, pyrazinamide and others.

     Assign inside (just before eating): adults to 0.25 g 3 times a day. The highest single dose of 0.25 g for adults, a daily dose of 1 year Patients over 60 years of age and weighing less than 50 kilograms have to 0.25 g 2 times a day. Daily dose for children at the rate of 0,01 - 0,02 g / kg, but not more than 0.75 grams per day, with a large dose given only in the acute phase of tuberculosis or lack of effectiveness of smaller doses.

     When treating tsikloserinom side effects may occur due mainly to the influence of drug toxicity to the nervous system: headache, dizziness, insomnia (or, rather, fall), anxiety, increased irritability, memory deterioration, paresthesia, peripheral neuritis. You may more severe symptoms: fear, psihostenicheskie state gallyutsinatornye phenomena epileptiformnye seizures, loss of consciousness.

     These events usually take place in dose reduction or elimination of the drug. Prevent or reduce the toxic effects tsikloserina possible, appointing during treatment glutaminovuyu acid 0.5 g of 3 - 4 times a day (to food); It is also recommended introduction vnutrimyshechnoe adenozintrifosfornoy acid sodium salt, and 1 mL of 1% solution every day. Sometimes effectively introduction pyridoxine (intramuscularly 1 - 2 mL of 5% solution in a day). If necessary, you can take protivosudorozhnye and sedatives means drugs.

     To reduce the adverse events should be limited to the mental stress of patients and exclude possible overheating (staying in the sun with their heads uncovered, hot shower, etc.) that could provoke complications.

     Contraindications: TSNS organic disease, epilepsy, mental violations, as well as in the history of ukaeany mental illness. You can not take Cycloserine before surgical procedures and in the first week after. With caution should appoint a drug violation in kidney function, people with fragile psyches suffering from alcoholism.

     In practice, use of outpatient care after testing its portability in a hospital.

     Form release: tablets or capsules in the city 0.25

     Storage: List B. In a dry, sheltered from the world scene with a temperature higher than 20 + C.

Materials allowed to copy only with the active hyperlink to the handbook of medicines