TSIKLOMETIAZID (Cyclomethiazidum). 3-Tsiklopentilmetil-6- hlor-7- sulfamoil-3, 4-digidro-1, 2, 4 benzotiadiazin-1, 1-dioxide.

     Synonyms: Cyclopenthiazide, Cyclopenthiazidum, Navidrex, Navidrix, Salimid, Zyklopenthiazid.

     White or white to light yellow crystalline white powder. Almost nerastvorim water easily soluble in alcohol.

     By building and pharmacological properties similar to dihlotiazidu. The chemical structure is the fact that one of the hydrogen atoms in the position since March replaced metiltsiklopentilnym Radical. Much more active than dihlotiazid that allows it to the lower doses.

     The product is well absorbed. Diuretichesky effect seen after 2 to 4 h after administration, with a maximum of 3 through 6 h. The total duration of the average therapeutic dose of about 10 - 12 hours Daily increases in Diurez 1 5 2 5 times.

     Indications for use are the same as for dihlotiazida.

     Assign inside tablets. In severe normally take to 0.0005 g (0.5 mg tablet = 1) per day (better morning), in more severe cases, 0,001 - 0.0015 g (2 to 3 tablets) a day. Increasing doses of more than 0,002 grams per day is not normally enhances the effect. Course length and the total duration of treatment are the same as for dihlotiazida.

     In hypertensive disease appoint 0.0005 g (1 tablet) on the day when combined with gipotenzivnymi means of 0.0005 g-2 3 times a week. Children are encouraged to take 0.00025 0.0005-g (1 / 2 - 1 tablet) per day or one every 2 to 3 days.

     Adverse events, preventive measures and contraindications are the same as for dihlotiazida.

     Form release: pills to 0.0005 g (0.5 mg) in a package of 20 pieces.

     Storage: List B. In sheltered from the world scene.

Materials allowed to copy only with the active hyperlink to the handbook of medicines