TSIANOKOBALAMIN (Cyanocobalaminum).

     VITAMIN B 12 (Vitaminum W 12).

     For a [a - (5, 6-Dimetilbenzimidazolil) - So-kobamidtsianid b, or a (5, 6 Dimethyl benzimidazolil) - kobamidtsianid.

     C inonimy: Actamin B12, Almeret, Anacobin, Antinem, Antipernicin, Arcavit B12, Bedodec, Bedoxyl, Bedumil, Berubigen, Biopar, Catavin, Cobastab, Cobavite, Cobione, Curibin, Cycobemin, Cycoplex, Cytacon, Cytamen, Cytobex, Cytobion, Dancavit B12 , Distivit, Dobetin, Dociton, Dodecavit, Emobione, Grisevit, Hepagon, Lentovit, Megalovel, Novivit, Pernapar, Redamin, Reticulogen, Rubavit, Rubivitan, Rubramin, Vibicon and others.

     Crystalline powder dark red odourless. Gigroskopichen. It is difficult to dissolve in water; Solutions are red (or pink) color. Sterilize solutions at the temperature of 100 + C for 30 min. In the long avtoklavirovanii vitamin destroyed. Reinstating Oxidizing substances (such as ascorbic acid), and salts of heavy metals contributed inactivation vitamin. Microflora quickly absorb vitamin B 12, so solutions should be kept in aseptic conditions.

     A characteristic feature of the chemical molecules Cyancobalamin it is a cobalt atom and Cyano Group, forming a coordinating set.

     Vitamin B 12 (cyancobalamin) tissues of animals do not. His synthesis of the natural microorganisms, mainly bacteria, aktinomitsetami, blue-green algae. In humans and animals synthesized intestinal microflora, which comes to the bodies accumulate in the greatest amounts in the kidneys, liver, bowel wall. Synthesis of bowel needs in the body of vitamin B 12 is not fully guaranteed; Additional quantities come from products of animal origin. Vitamin B 12 is contained in different quantities in medical products derived from the liver of animals (see Vitogepat).

     In the body cyancobalamin into kofermentnuyu adenozilkobalamin form, or kobamamid (see), which is the active form of vitamin B 12.

     Cyancobalamin has high biological activity. Is growth factor essential for the normal maturation of blood and blood; Involved in the synthesis labilnyh metilnyh groups and education choline, methionine, creatine, nucleic acids; To accumulate in the blood compounds containing sulfgidrilnye group. Provides a good effect on liver function and the nervous system.

     Cyancobalamin svertyvayuschuyu system activates blood; In high doses, is increasing tromboplasticheskoy activity and activity protrombina.

     It activates the exchange of carbohydrates and lipids. When atherosclerosis slightly lowers cholesterol content in the blood increases letsitinholesterinovy index.

     Cyancobalamin has expressed curative effect on disease-Addisona Birmera, agastricheskih anemia (after stomach Research), and anaemia in connection with polyposis and syphilis stomach, and anemia accompanying ac, and other pernitsioznopodobnyh anemia, including the invasion caused widespread lentetsom, during pregnancy, disease, etc.

     For use as a medicine receive vitamin B 12 microbiological method of synthesis.

     Vitamin B 12 is a highly protivoanemicheskim drug. This product successfully used for the treatment of malignant anaemia, and with postgemorragicheskih zhelezodefitsitnyh anemia, la anemia among children, the nature of nutritional anemia, anemia caused by toxic substances and drugs, and other forms of anaemia.

     Assign well as radiation sickness, malnutrition among premature babies and transferred after infection with disease (along with folic acid), liver disease (Botkina disease, hepatitis, cirrhosis), polinevritah, sciatica, neuralgia troynichnogo nerve, diabetic neuritis, kauzalgiyah, migraine , alcohol deliriume, amiotroficheskom lateral sclerosis, infant cerebral paralysis, Dawna diseases, skin diseases (psoriasis, fotodermatozy, gerpetiformny dermatitis, Neurodermatitis etc.).

     Cyancobalamin impose intramuscularly, subcutaneously, and intralyumbalno intravenously.

     Vitamin B 12 poorly absorbed in the employment inside. Suction improved somewhat in the appointment, along with folic acid.

     When anemia associated with low vitamin B 12 to impose 100-200 µ g (0.1 - 0.2 mg) 1 every 2 days; When anemia with phenomena funikulyarnogo mieloza and makrotsitarnyh anemia with defeats nervous system-500 µ g and more on injection (in the first week of the day, and thereafter at intervals of a 5-to 7 days). At the same time, designate folic acid.

     During remission in the absence of events funikulyarnogo mieloza impose supportive therapy for 100 ug two times a month, and if nevrologichesiih events - 200-400 ug 2 to 4 times a month.

     In postgemorragicheskih zhelezodefitsitnyh anemia and appoint 30-100 µ g 2 -3 times a week; When al anemia in childhood-100 ug before clinical hematology improvements; When nutritional anaemia of early childhood and anemia in premature for the 30 - µ g within 15 days.

     When the disease agent (amiotrofichesky lateral sclerosis, entsefalomielit etc.) and neurological diseases with pain syndrome give increasing doses of 200 to 500 µ g / injection, while improving on the 100 µ g / day; Treatment up to 2 weeks. With traumatic defeat peripheral nerves appoint 200-400 ug 1 every 2 days during 40-45 days.

     When hepatitis and liver cirrhosis designate (adults and children) to 30-60 µ g / day or 100 ug a day for 25 to 40 days.

     Children at an early age with Dystrophic condition after deferred diseases, diseases Dawna and infant cerebral paralysis encouraged to nominate 15 - 30 ug a day.

     In disease, radiation sickness, diabetic neuropathy and other diseases of vitamin B 12 is usually appointed to 60-100 µ g daily for 20 to 30 days.

     For treatment funikulyarnogo mieloza, vector lateral sclerosis, type of MS sometimes in the spinal canal 15 - 30 ug (gradually increasing the dose to 200-250 ug).

     Treatment of vitamin B 12 combined, as needed, with the appointment of other medicines.

     When expressed polinevriticheskom syndrome appoint a vitamin B 1; In gastric secretory deficiency systematically take digestive juice or divorced hydrochloric acid.

     If the treatment is a low color, as well as anemia gipohromnyh appoint additional iron products (often in conjunction with the 0.1 - 0.2 g ascorbic acid).

     Cyancobalamin usually well tolerated by. With heightened sensitivity to the drug phenomenon can be observed allergic, nervous excitement, pain in the heart, tachycardia. When there should temporarily stop receiving the drug, and subsequently appointed him in small doses (15 to 30 µ g).

     If treatment tsianokobalaminom be systematically blood. In trend towards eritro- leykotsitoza dose and reduce or temporarily stop treatment. In the treatment process to be controlled blood coagulability and care for individuals with incentives to tromboobrazovaniyu. We can not impose vitamin In 12 patients with severe tromboembolicheskimi diseases.

     For patients with stenocardia vitamin B 12 should be applied with caution and in smaller doses (up to 100 µ g / injection).

     Not recommended introduction of joint (a syringe) solutions of vitamins B 12, in January and in June as contained in the molecule Cyancobalamin cobalt ion to the destruction of other vitamins. It should also be borne in mind that vitamin B 12 may increase allergic reactions caused by vitamin B 1.

     Cyancobalamin contraindications in acute pulmonary, eritremii, eritrotsitoze.

     Form release: in the ampoule containing at Z0; 100; 200 and 500 ug Cyancobalamin in 1 ml isotonic sodium chloride solution (ie 1 ml of 0.003%, 0.01%, 0.02% and 0.05 % solution).

     Storage: in sheltered from the world scene.

     R p. : Sol. Souah n main b and l and mini 0,01% 1 ml

     D.t.d. N. in ampull 10.

     S. At 1 ml intramuscularly

     Cyancobalamin part of the combined (multivitamin) drugs (see Gendevit, Kvadevit, Komplivit etc.).

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